The Agminosides: Naturally Acetylated Glycolipids from the New Zealand Marine Sponge Raspailia agminata

Examination of the New Zealand sponge Raspailia agminata resulted in the isolation of five members of a novel family of glycolipids, agminosides A−E (1−5). These large and complex molecules contain up to six partially acetylated glucose residues. The chromatographic separation of these compounds was...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2011-01, Vol.74 (1), p.69-73
Main Authors: Wojnar, Joanna M, Northcote, Peter T
Format: Article
Language:English
Subjects:
Acetylation
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Glycolipids - chemistry
Glycolipids - isolation & purification
Lipids
Marine Biology
Miscellaneous
Molecular Structure
New Zealand
Nuclear Magnetic Resonance, Biomolecular
Other biological molecules
Porifera - chemistry
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Summary:Examination of the New Zealand sponge Raspailia agminata resulted in the isolation of five members of a novel family of glycolipids, agminosides A−E (1−5). These large and complex molecules contain up to six partially acetylated glucose residues. The chromatographic separation of these compounds was a challenge due to the similarity of the congeners and their lack of a chromophore. MS-guided isolation followed by extensive NMR analysis and chemical derivatization eventually led to the purification and identification of 1−5.
ISSN:0163-3864
1520-6025
DOI:10.1021/np100710c