Plasma Platelet-derived Microparticles in Patients with Connective Tissue Diseases

To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). Plasma levels of PD...

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Bibliographic Details
Published in:Journal of rheumatology 2011-04, Vol.38 (4), p.680-684
Main Authors: OYABU, Chinami, MORINOBU, Akio, SUGIYAMA, Daisuke, SAEGUSA, Jun, TANAKA, Shino, MORINOBU, Sahoko, TSUJI, Goh, KASAGI, Shimpei, KAWANO, Seiji, KUMAGAI, Shunichi
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood and lymphatic vessels
Blood Platelets - chemistry
Cardiology. Vascular system
Cell-Derived Microparticles - metabolism
Connective Tissue Diseases - blood
Dermatology
Dermatomyositis - blood
Diseases of the osteoarticular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Humans
Male
Medical sciences
Middle Aged
Mixed Connective Tissue Disease - blood
Polymyositis - blood
Raynaud Disease - blood
Scleroderma, Systemic - blood
Vascular disorders of the skin
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Summary:To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined. PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months. PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP.
ISSN:0315-162X
1499-2752
DOI:10.3899/jrheum.100780