Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor

Objective The purpose of this study was to compare the chemotactic activity of the choriodecidua and amnion, and to identify the phenotype of the leukocytes chemoattracted by each tissue. Study Design Amnion, choriodecidua and whole fetal membranes extracts were obtained from women at term (>37 w...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2011-04, Vol.204 (4), p.364.e9-364.e16
Main Authors: Gomez-Lopez, Nardhy, MSc, PhD, Vadillo-Perez, Lourdes, Nessim, Shereen, BSc, Olson, David M., PhD, FRCOG, Vadillo-Ortega, Felipe, MD, PhD
Format: Article
Language:English
Subjects:
amnion
Amnion - metabolism
chemotaxis
Chemotaxis, Leukocyte
choriodecidua
Chorion - metabolism
Decidua - metabolism
Extraembryonic Membranes - metabolism
Female
fetal membranes
Flow Cytometry
Humans
labor
Labor, Obstetric
leukocytes
Leukocytes - metabolism
Obstetrics and Gynecology
Pregnancy
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Summary:Objective The purpose of this study was to compare the chemotactic activity of the choriodecidua and amnion, and to identify the phenotype of the leukocytes chemoattracted by each tissue. Study Design Amnion, choriodecidua and whole fetal membranes extracts were obtained from women at term (>37 weeks of gestation) with or without labor (n = 5 each). Extracts were assayed for leukocyte chemotactic activity, and the number and phenotype of the chemoattracted leukocytes were characterized by flow cytometry. Results Although all of the extracts exhibited chemotactic activity, more leukocytes were chemoattracted by the choriodecidua and the whole fetal membranes during labor compared with no labor ( P = .010, .008). During labor the choriodecidua is responsible for granulocyte, T-lymphocyte, monocyte, and natural killer-cell chemoattraction, and the amnion is responsible for B-lymphocyte chemoattraction. Conclusion Choriodecidua and amnion exhibit chemotactic activity for selective leukocytes and thus, each fetal membrane differentially regulates leukocyte chemotactic activity during labor.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2010.11.010