Altered Expression of Cell Cycle and Apoptotic Proteins in Human Liver Pathologies

• Published in: Anticancer research 2010-11, Vol.30 (11), p.4493-4501
• Main Authors: MITSELOU, Antigony, KARAPIPERIDES, Damianos, NESSERIS, Ioannis, VOUGIOUKLAKIS, Theodoros, AGNANTIS, Niki J
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Apoptosis; bcl-2-Associated X Protein - metabolism; Biological and medical sciences; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Cycle Proteins - metabolism; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Fatty Liver - metabolism; Fatty Liver - pathology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunoenzyme Techniques; Ki-67 Antigen - metabolism; Liver - metabolism; Liver - pathology; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Proto-Oncogene Proteins c-bcl-2 - metabolism; Tumor Suppressor Protein p53 - metabolism; Tumors
• ISSN: 0250-7005; 1791-7530

Τhe expression of cell cycle (P53, Ki-67, P21, and P27) and apoptotic proteins (BCL-2 and BAX) was investigated by immunohistochemistry in paraffin-embedded formalin-fixed tissues of normal and pathologic liver. An increased frequency of expression of P21 in cirrhosis and hepatocellular carcinoma (HCC) (p=0.003 and p=0.001 respectively) was found; P27 protein expression was more frequent in hepatitis (p=0.001) and HCC (p=0.003) when compared with normal tissue. BCL-2 protein was markedly more frequent in steatohepatitis (p