Loading…
Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients
Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab s...
Saved in:
| Published in: | Journal of neurology 2011-03, Vol.258 (3), p.464-470 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3 |
| container_end_page | 470 |
| container_issue | 3 |
| container_start_page | 464 |
| container_title | Journal of neurology |
| container_volume | 258 |
| creator | Akman-Demir, Gulsen Tüzün, Erdem Waters, Patrick İçöz, Sema Kürtüncü, Murat Jarius, Sven Yapıcı, Zuhal Mutlu, Melike Yeşilot, Nilüfer Vincent, Angela Eraksoy, Mefkure |
| description | Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish patients with NMO to determine the clinical and prognostic relevance. Serum samples from 35 consecutive patients with NMO followed at a single center and diagnosed according to the 2006 revised criteria, were evaluated for Aqp-4-Ab. All samples were obtained during a relapse prior to any immunosuppressive treatment. Aqp-4-Ab was positive in 21/35 (60%) patients. Among these cases, 11 had an EDSS of 6.0 or more, whereas only two patients in the seronegative group had such severe disability (
p
|
| doi_str_mv | 10.1007/s00415-010-5780-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860378323</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2280090391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6A7xII4in1spXJznK4hcs6EHxGKoz6SVLd9KbpA_z7zfDjC4I4imH96k3VTyEvKTwjgKo9wVAUNkDhV4qDb14RHZUcNZTIc1jsgMuWsKluCDPSrkFAN2Cp-SCgZHcDLAjv77ndBNTqcF1YVnn4LCGFEuXpg7vNlxTDrEXHcYaxrQ_dKVi3UoXYhf9ltNy8HOoofFrq8BubeM-1vKcPJlwLv7F-b0kPz99_HH1pb_-9vnr1Yfr3gmjaz9Q51EZRrkamWB0wmngcjLDHgdx3FcBaqTG68Gj9KNUnIJSfBy4a6fv-SV5e-pdc7rbfKl2CcX5ecbo01asHoArzRn_Pyklg0FR2sjXf5G3acuxndEgwQ3TWjeIniCXUynZT3bNYcF8sBTs0Y492bHNjj3asaLNvDoXb-Pi938mfutowJszgMXhPGWMLpQHjhstm8PGsRNXWhRvfH7Y8N-_3wP03aZc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>854392888</pqid></control><display><type>article</type><title>Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients</title><source>Springer Link</source><creator>Akman-Demir, Gulsen ; Tüzün, Erdem ; Waters, Patrick ; İçöz, Sema ; Kürtüncü, Murat ; Jarius, Sven ; Yapıcı, Zuhal ; Mutlu, Melike ; Yeşilot, Nilüfer ; Vincent, Angela ; Eraksoy, Mefkure</creator><creatorcontrib>Akman-Demir, Gulsen ; Tüzün, Erdem ; Waters, Patrick ; İçöz, Sema ; Kürtüncü, Murat ; Jarius, Sven ; Yapıcı, Zuhal ; Mutlu, Melike ; Yeşilot, Nilüfer ; Vincent, Angela ; Eraksoy, Mefkure</creatorcontrib><description>Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish patients with NMO to determine the clinical and prognostic relevance. Serum samples from 35 consecutive patients with NMO followed at a single center and diagnosed according to the 2006 revised criteria, were evaluated for Aqp-4-Ab. All samples were obtained during a relapse prior to any immunosuppressive treatment. Aqp-4-Ab was positive in 21/35 (60%) patients. Among these cases, 11 had an EDSS of 6.0 or more, whereas only two patients in the seronegative group had such severe disability (
p
< 0.05). Overall, seropositive cases had a mean EDSS score of 5.1 ± 2.2 compared with 3.5 ± 1.7 in seronegative cases (
p
< 0.01). There were trends towards female predominance in seropositive cases and a monophasic course predominance in seronegative cases. Disease duration, age at onset, number of attacks and time to definite NMO did not differ between groups. Our findings in this single-center cohort suggest that the presence of Aqp-4-Ab might have a prognostic significance indicating a more severe disease course.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-010-5780-4</identifier><identifier>PMID: 20953960</identifier><identifier>CODEN: JNRYA9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Antibodies ; Aquaporin 4 - blood ; Aquaporins ; Autoantibodies - biosynthesis ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - blood ; Child ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple sclerosis ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - diagnosis ; Neuromyelitis Optica - epidemiology ; Neuroradiology ; Neurosciences ; Original Communication ; Patients ; Prognosis ; Spinal cord ; Turkey - epidemiology ; Young Adult</subject><ispartof>Journal of neurology, 2011-03, Vol.258 (3), p.464-470</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3</citedby><cites>FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23985084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20953960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akman-Demir, Gulsen</creatorcontrib><creatorcontrib>Tüzün, Erdem</creatorcontrib><creatorcontrib>Waters, Patrick</creatorcontrib><creatorcontrib>İçöz, Sema</creatorcontrib><creatorcontrib>Kürtüncü, Murat</creatorcontrib><creatorcontrib>Jarius, Sven</creatorcontrib><creatorcontrib>Yapıcı, Zuhal</creatorcontrib><creatorcontrib>Mutlu, Melike</creatorcontrib><creatorcontrib>Yeşilot, Nilüfer</creatorcontrib><creatorcontrib>Vincent, Angela</creatorcontrib><creatorcontrib>Eraksoy, Mefkure</creatorcontrib><title>Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish patients with NMO to determine the clinical and prognostic relevance. Serum samples from 35 consecutive patients with NMO followed at a single center and diagnosed according to the 2006 revised criteria, were evaluated for Aqp-4-Ab. All samples were obtained during a relapse prior to any immunosuppressive treatment. Aqp-4-Ab was positive in 21/35 (60%) patients. Among these cases, 11 had an EDSS of 6.0 or more, whereas only two patients in the seronegative group had such severe disability (
p
< 0.05). Overall, seropositive cases had a mean EDSS score of 5.1 ± 2.2 compared with 3.5 ± 1.7 in seronegative cases (
p
< 0.01). There were trends towards female predominance in seropositive cases and a monophasic course predominance in seronegative cases. Disease duration, age at onset, number of attacks and time to definite NMO did not differ between groups. Our findings in this single-center cohort suggest that the presence of Aqp-4-Ab might have a prognostic significance indicating a more severe disease course.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Aquaporin 4 - blood</subject><subject>Aquaporins</subject><subject>Autoantibodies - biosynthesis</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - diagnosis</subject><subject>Neuromyelitis Optica - epidemiology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Spinal cord</subject><subject>Turkey - epidemiology</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkU2LFDEQhoMo7rj6A7xII4in1spXJznK4hcs6EHxGKoz6SVLd9KbpA_z7zfDjC4I4imH96k3VTyEvKTwjgKo9wVAUNkDhV4qDb14RHZUcNZTIc1jsgMuWsKluCDPSrkFAN2Cp-SCgZHcDLAjv77ndBNTqcF1YVnn4LCGFEuXpg7vNlxTDrEXHcYaxrQ_dKVi3UoXYhf9ltNy8HOoofFrq8BubeM-1vKcPJlwLv7F-b0kPz99_HH1pb_-9vnr1Yfr3gmjaz9Q51EZRrkamWB0wmngcjLDHgdx3FcBaqTG68Gj9KNUnIJSfBy4a6fv-SV5e-pdc7rbfKl2CcX5ecbo01asHoArzRn_Pyklg0FR2sjXf5G3acuxndEgwQ3TWjeIniCXUynZT3bNYcF8sBTs0Y492bHNjj3asaLNvDoXb-Pi938mfutowJszgMXhPGWMLpQHjhstm8PGsRNXWhRvfH7Y8N-_3wP03aZc</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Akman-Demir, Gulsen</creator><creator>Tüzün, Erdem</creator><creator>Waters, Patrick</creator><creator>İçöz, Sema</creator><creator>Kürtüncü, Murat</creator><creator>Jarius, Sven</creator><creator>Yapıcı, Zuhal</creator><creator>Mutlu, Melike</creator><creator>Yeşilot, Nilüfer</creator><creator>Vincent, Angela</creator><creator>Eraksoy, Mefkure</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients</title><author>Akman-Demir, Gulsen ; Tüzün, Erdem ; Waters, Patrick ; İçöz, Sema ; Kürtüncü, Murat ; Jarius, Sven ; Yapıcı, Zuhal ; Mutlu, Melike ; Yeşilot, Nilüfer ; Vincent, Angela ; Eraksoy, Mefkure</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Aquaporin 4 - blood</topic><topic>Aquaporins</topic><topic>Autoantibodies - biosynthesis</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - diagnosis</topic><topic>Neuromyelitis Optica - epidemiology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Spinal cord</topic><topic>Turkey - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akman-Demir, Gulsen</creatorcontrib><creatorcontrib>Tüzün, Erdem</creatorcontrib><creatorcontrib>Waters, Patrick</creatorcontrib><creatorcontrib>İçöz, Sema</creatorcontrib><creatorcontrib>Kürtüncü, Murat</creatorcontrib><creatorcontrib>Jarius, Sven</creatorcontrib><creatorcontrib>Yapıcı, Zuhal</creatorcontrib><creatorcontrib>Mutlu, Melike</creatorcontrib><creatorcontrib>Yeşilot, Nilüfer</creatorcontrib><creatorcontrib>Vincent, Angela</creatorcontrib><creatorcontrib>Eraksoy, Mefkure</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akman-Demir, Gulsen</au><au>Tüzün, Erdem</au><au>Waters, Patrick</au><au>İçöz, Sema</au><au>Kürtüncü, Murat</au><au>Jarius, Sven</au><au>Yapıcı, Zuhal</au><au>Mutlu, Melike</au><au>Yeşilot, Nilüfer</au><au>Vincent, Angela</au><au>Eraksoy, Mefkure</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>258</volume><issue>3</issue><spage>464</spage><epage>470</epage><pages>464-470</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><coden>JNRYA9</coden><abstract>Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish patients with NMO to determine the clinical and prognostic relevance. Serum samples from 35 consecutive patients with NMO followed at a single center and diagnosed according to the 2006 revised criteria, were evaluated for Aqp-4-Ab. All samples were obtained during a relapse prior to any immunosuppressive treatment. Aqp-4-Ab was positive in 21/35 (60%) patients. Among these cases, 11 had an EDSS of 6.0 or more, whereas only two patients in the seronegative group had such severe disability (
p
< 0.05). Overall, seropositive cases had a mean EDSS score of 5.1 ± 2.2 compared with 3.5 ± 1.7 in seronegative cases (
p
< 0.01). There were trends towards female predominance in seropositive cases and a monophasic course predominance in seronegative cases. Disease duration, age at onset, number of attacks and time to definite NMO did not differ between groups. Our findings in this single-center cohort suggest that the presence of Aqp-4-Ab might have a prognostic significance indicating a more severe disease course.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20953960</pmid><doi>10.1007/s00415-010-5780-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5354 |
| ispartof | Journal of neurology, 2011-03, Vol.258 (3), p.464-470 |
| issn | 0340-5354 1432-1459 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_860378323 |
| source | Springer Link |
| subjects | Adolescent Adult Antibodies Aquaporin 4 - blood Aquaporins Autoantibodies - biosynthesis Autoantibodies - blood Biological and medical sciences Biomarkers - blood Child Female Follow-Up Studies Humans Magnetic Resonance Imaging - methods Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuromyelitis Optica - blood Neuromyelitis Optica - diagnosis Neuromyelitis Optica - epidemiology Neuroradiology Neurosciences Original Communication Patients Prognosis Spinal cord Turkey - epidemiology Young Adult |
| title | Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A23%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20implications%20of%20aquaporin-4%20antibody%20status%20in%20neuromyelitis%20optica%20patients&rft.jtitle=Journal%20of%20neurology&rft.au=Akman-Demir,%20Gulsen&rft.date=2011-03-01&rft.volume=258&rft.issue=3&rft.spage=464&rft.epage=470&rft.pages=464-470&rft.issn=0340-5354&rft.eissn=1432-1459&rft.coden=JNRYA9&rft_id=info:doi/10.1007/s00415-010-5780-4&rft_dat=%3Cproquest_cross%3E2280090391%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c498t-61cea792137b2421faf635f96da64000870a8a19e86ea5eb57310773b63c415d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=854392888&rft_id=info:pmid/20953960&rfr_iscdi=true |