Outcome prediction in sepsis combined use of genetic polymorphisms – A study in Japanese population

• Published in: Cytokine (Philadelphia, Pa.) Pa.), 2011-04, Vol.54 (1), p.79-84
• Main Authors: Shimada, Tadanaga, Oda, Shigeto, Sadahiro, Tomohito, Nakamura, Masataka, Hirayama, Yoh, Watanabe, Eizo, Abe, Ryuzo, Nakada, Taka-aki, Tateishi, Yoshihisa, Otani, Shunsuke, Hirasawa, Hiroyuki, Tokuhisa, Takeshi, Uno, Hajime
• Format: Article
• Language: English
• Subjects: Age; Aged; APACHE; Area Under Curve; Cytokines; Demography; disease severity; Female; Gene polymorphism; genetic polymorphism; Genetics; Humans; Inflammation; Intensive Care Units; Interleukin 1; Interleukin-6 - blood; Japan; Male; medical history; Middle Aged; Models, Genetic; Mortality; patients; Polymorphism, Genetic; Population studies; prediction; Regression analysis; Risk factors; ROC Curve; Sepsis; Sepsis - blood; Sepsis - genetics; Sex; Treatment Outcome; Tumor necrosis factor
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2010.12.001

Genetic polymorphisms have recently been found to be related to clinical outcome in septic patients. The present study investigated to evaluate the influence of genetic polymorphisms in Japanese septic patients on clinical outcome and whether use of genetic polymorphisms as predictors would enable more accurate prediction of outcome. Effects of 16 genetic polymorphisms related to pro-inflammatory mediators and conventional demographic/clinical parameters (age, sex, past medical history, and APACHE II score) on ICU mortality as well as disease severity during ICU stay were examined in the septic patients (n=123) admitted to the ICU between October 2001 and November 2007 by multivariable logistic regression analysis. ICU mortality was significantly associated with TNF −308GA, IL1β −31CT/TT, and APACHE II score. Receiver-operating characteristics (ROC) analysis demonstrated that, compared with APACHE II score alone (ROC–AUC=0.68), use of APACHE II score and two genetic parameters (TNF −308 and IL1β −31) enabled more accurate prediction of ICU mortality (ROC–AUC=0.80). Significant association of two genetic polymorphisms, TNF −308 and IL1β −31, with ICU mortality was observed in septic patients. In addition, combined use of these genetic parameters with APACHE II score may enable more accurate prediction of outcome in septic patients.