Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone

▶ PFC dopamine and norepinephrine are implicated in impulsivity deficits. ▶ Prolonged ITI induced high levels of impulsivity in rats in 5-CSRTT. ▶ Tolcapone selectively enhances PFC dopamine, not norepinephrine. ▶ The COMT inhibitor tolcapone had no effects on the increased impulsivity. ▶ Data sugge...

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Bibliographic Details
Published in:Neuroscience research 2011, Vol.69 (1), p.41-50
Main Authors: Paterson, Neil E., Ricciardi, Jennifer, Wetzler, Caitlin, Hanania, Taleen
Format: Article
Language:English
Subjects:
5-CSRTT
Adrenergic Uptake Inhibitors - pharmacology
Animals
Atomoxetine
Atomoxetine Hydrochloride
Attention
Attention - drug effects
Attention - physiology
Benzophenones - pharmacology
Catechol O-Methyltransferase Inhibitors
Central Nervous System Stimulants - pharmacology
Choice Behavior - drug effects
Choice Behavior - physiology
d-Amphetamine
Dextroamphetamine - pharmacology
Dopamine - pharmacology
Dopamine Uptake Inhibitors - pharmacology
Dose-Response Relationship, Drug
Impulsive Behavior - drug therapy
Impulsivity
Male
Methylphenidate
Methylphenidate - pharmacology
Nitrophenols - pharmacology
Norepinephrine - pharmacology
Prefrontal Cortex - drug effects
Propylamines - pharmacology
Rat
Rats
Rats, Long-Evans
Reaction Time - drug effects
Reaction Time - physiology
Tolcapone
Variable inter-trial interval
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Summary:▶ PFC dopamine and norepinephrine are implicated in impulsivity deficits. ▶ Prolonged ITI induced high levels of impulsivity in rats in 5-CSRTT. ▶ Tolcapone selectively enhances PFC dopamine, not norepinephrine. ▶ The COMT inhibitor tolcapone had no effects on the increased impulsivity. ▶ Data suggest PFC dopamine is not involved in impulsivity deficits in the 5-CSRTT. Prefrontal cortical dopamine (DA) and norepinephrine (NE) are implicated in multiple aspects of cognitive function assessed via the 5-choice serial reaction time task (5-CSRTT) in rodents. The present studies assessed the effects of the NE reuptake inhibitor atomoxetine (0.5–2.0 mg/kg), the mixed DA/NE reuptake inhibitor methylphenidate (0.1–2.0 mg/kg), the catecholamine releaser d-amphetamine (0.1–1.0 mg/kg) and the catecholamine-o-methyl-transferase (COMT) inhibitor tolcapone (3.0–30.0 mg/kg) in rats that exhibited sub-optimal performance (reduced accuracy:
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2010.10.001