Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats

The effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices were investigated in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered artesunate (2m...

Full description

Saved in:
Bibliographic Details
Published in:Food and chemical toxicology 2011-01, Vol.49 (1), p.45-48
Main Authors: Adebayo, J.O., Igunnu, A., Arise, R.O., Malomo, S.O.
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Alkaline Phosphatase - metabolism
Amodiaquine - administration & dosage
Animals
Antimalarial
Artemisinins - administration & dosage
Biological and medical sciences
blood lipids
blood serum
Body weight
Cardiovascular
Cardiovascular Diseases - prevention & control
Cholesterol
Cholesterol - blood
Control equipment
coronary disease
Drug toxicity and drugs side effects treatment
drugs
Heart
Heart diseases
high density lipoprotein cholesterol
laboratory animals
Lipids
low density lipoprotein cholesterol
Malondialdehyde - metabolism
Medical sciences
Myocardium - enzymology
Myocardium - metabolism
oral administration
patients
Pharmacology. Drug treatments
Rats
Rattus
Serums
Toxicity
Toxicity: cardiovascular system
toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices were investigated in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered artesunate (2mg/kg body weight), those administered amodiaquine (6.12mg/kg body weight) and those co-administered artesunate (2mg/kg body weight) and amodiaquine (6.12mg/kg body weight). The drugs were orally administered twice daily for three days after which the serum lipid profile, heart MDA content and heart ALP and ACP activities were determined. Artesunate significantly reduced (P0.05) on other parameters compared to controls. Amodiaquine, on the other hand, significantly reduced (P
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2010.09.022