Evaluation of freeze-dried pregelatinized Chinese yam (Dioscorea oppositifolia) starch as a polymer in floating gastroretentive metformin microbeads

Pregelatinized Chinese yam (Dioscorea oppositifolia) starch has been evaluated as a polymer for the formulation of floating gastroretentive beads for the controlled delivery of metformin hydrochloride. Floating microbeads were prepared by the ionotropic gelation method using a blend of modified Chin...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2010, Vol.20 (6), p.457-465
Main Authors: Okunlola, A., Patel, R.P., Odeku, O.A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chinese yam starch
Controlled drug delivery
Dioscorea
Floating microbeads
General pharmacology
Medical sciences
Metformin hydrochloride
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Release kinetics
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Summary:Pregelatinized Chinese yam (Dioscorea oppositifolia) starch has been evaluated as a polymer for the formulation of floating gastroretentive beads for the controlled delivery of metformin hydrochloride. Floating microbeads were prepared by the ionotropic gelation method using a blend of modified Chinese yam starch and sodium alginate at different ratios. Sodium bicarbonate was added as a gas-generating agent. The floating microbeads were characterized by SEM, DSC, FTIR analyses and the drug entrapment efficiency and floating ability was evaluated. Drug release was investigated using in vitro dissolution test and the results were fitted to various kinetic models to determine the mechanism(s) of release. Spherical, discrete and free flowing microbeads were obtained from the modified starch-alginate blends. Minimum lag time (
ISSN:1773-2247
DOI:10.1016/S1773-2247(10)50079-0