From the vascular microenvironment to neurogenesis

Abstract In response to injury, the function of the adult mammalian central nervous system (CNS) is repaired by angiogenesis and neurogenesis. The proliferation, differentiation and migration of the neural progenitor cells (NPCs) are regulated by several components of the vascular microenvironment w...

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Bibliographic Details
Published in:Brain research bulletin 2011-01, Vol.84 (1), p.1-7
Main Authors: Yang, Xi-Tao, Bi, Yong-Yan, Feng, Dong-Fu
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Blood Vessels - cytology
Cell Differentiation - physiology
Cell Proliferation
Differentiation
Endothelial Cells - cytology
Endothelial Cells - physiology
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Migration
Neural progenitor cells
Neural Stem Cells - cytology
Neural Stem Cells - physiology
Neurogenesis
Neurogenesis - physiology
Neurology
Proliferation
Stem Cell Niche
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Summary:Abstract In response to injury, the function of the adult mammalian central nervous system (CNS) is repaired by angiogenesis and neurogenesis. The proliferation, differentiation and migration of the neural progenitor cells (NPCs) are regulated by several components of the vascular microenvironment within the neural stem cell niche. Vascular endothelial cells (VECs), which make up blood vessels, as well as extracellular components, affect neurogenesis directly via contacting with NPCs. Additionally, soluble factors from the vascular system that are released into the CNS enhance neurogenesis in the form of paracrine signaling. The purpose of this mini-review is to highlight the roles of the vascular microenvironment as a mediator in promoting neurogenesis.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2010.09.008