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Expression of Anti-apoptosis Genes Determines the Response of Adrenal Cancer to Apoptosis-inducing Chemotherapy
This study tested the hypothesis that response of adrenal cortical carcinoma (ACC) to pro-apoptosis drugs depends on expression of anti-apoptosis genes. Expression of Bcl-2 and Bcl-XL proteins was determined in two human adrenal cancer cell lines, NCI-H-295 and RL-251. Two pro-apoptosis drugs, gossy...
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| Published in: | Anticancer research 2010-12, Vol.30 (12), p.4805-4809 |
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| container_end_page | 4809 |
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| container_title | Anticancer research |
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| creator | SCHTEINGART, David E BENITEZ, Ricardo BRADFORD, Carol NARAYAN, Ajita SHAOMENG WANG |
| description | This study tested the hypothesis that response of adrenal cortical carcinoma (ACC) to pro-apoptosis drugs depends on expression of anti-apoptosis genes.
Expression of Bcl-2 and Bcl-XL proteins was determined in two human adrenal cancer cell lines, NCI-H-295 and RL-251. Two pro-apoptosis drugs, gossypol (G) and docetaxel (D) were tested in vitro and in vivo in a human ACC/SCID mouse chimera.
Bcl-XL was strongly expressed in RL-251 but not in H-295 and neither expressed the Bcl-2 protein. G and D induced greater dose-dependent inhibition of cell proliferation in RL-251 than in H-295 cells and completely suppressed growth of tumors with high expression of Bcl-XL (p |
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Expression of Bcl-2 and Bcl-XL proteins was determined in two human adrenal cancer cell lines, NCI-H-295 and RL-251. Two pro-apoptosis drugs, gossypol (G) and docetaxel (D) were tested in vitro and in vivo in a human ACC/SCID mouse chimera.
Bcl-XL was strongly expressed in RL-251 but not in H-295 and neither expressed the Bcl-2 protein. G and D induced greater dose-dependent inhibition of cell proliferation in RL-251 than in H-295 cells and completely suppressed growth of tumors with high expression of Bcl-XL (p<0.05) while there was no growth suppression in tumors without Bcl-XL expression.
This study provided proof of concept that expression of Bcl-XL determines response to pro-apoptosis drugs. Profiling adrenal tumors for expression of anti-apoptosis genes may provide clues to their potential response to drugs that induce apoptosis.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 21187456</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adrenal Cortex Neoplasms - drug therapy ; Adrenal Cortex Neoplasms - genetics ; Adrenal Cortex Neoplasms - metabolism ; Adrenal Cortex Neoplasms - pathology ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Animals ; Apoptosis - drug effects ; Apoptosis - genetics ; bcl-X Protein - biosynthesis ; bcl-X Protein - genetics ; Biological and medical sciences ; Cell Line, Tumor ; Endocrinopathies ; Genes, bcl-2 ; Gossypol - pharmacology ; Humans ; Malignant tumors ; Medical sciences ; Mice ; Mice, SCID ; Proto-Oncogene Proteins c-bcl-2 - biosynthesis ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Taxoids - pharmacology ; Tumors</subject><ispartof>Anticancer research, 2010-12, Vol.30 (12), p.4805-4809</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23653041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21187456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHTEINGART, David E</creatorcontrib><creatorcontrib>BENITEZ, Ricardo</creatorcontrib><creatorcontrib>BRADFORD, Carol</creatorcontrib><creatorcontrib>NARAYAN, Ajita</creatorcontrib><creatorcontrib>SHAOMENG WANG</creatorcontrib><title>Expression of Anti-apoptosis Genes Determines the Response of Adrenal Cancer to Apoptosis-inducing Chemotherapy</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>This study tested the hypothesis that response of adrenal cortical carcinoma (ACC) to pro-apoptosis drugs depends on expression of anti-apoptosis genes.
Expression of Bcl-2 and Bcl-XL proteins was determined in two human adrenal cancer cell lines, NCI-H-295 and RL-251. Two pro-apoptosis drugs, gossypol (G) and docetaxel (D) were tested in vitro and in vivo in a human ACC/SCID mouse chimera.
Bcl-XL was strongly expressed in RL-251 but not in H-295 and neither expressed the Bcl-2 protein. G and D induced greater dose-dependent inhibition of cell proliferation in RL-251 than in H-295 cells and completely suppressed growth of tumors with high expression of Bcl-XL (p<0.05) while there was no growth suppression in tumors without Bcl-XL expression.
This study provided proof of concept that expression of Bcl-XL determines response to pro-apoptosis drugs. Profiling adrenal tumors for expression of anti-apoptosis genes may provide clues to their potential response to drugs that induce apoptosis.</description><subject>Adrenal Cortex Neoplasms - drug therapy</subject><subject>Adrenal Cortex Neoplasms - genetics</subject><subject>Adrenal Cortex Neoplasms - metabolism</subject><subject>Adrenal Cortex Neoplasms - pathology</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>bcl-X Protein - biosynthesis</subject><subject>bcl-X Protein - genetics</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Endocrinopathies</subject><subject>Genes, bcl-2</subject><subject>Gossypol - pharmacology</subject><subject>Humans</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Taxoids - pharmacology</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkU9LxDAQxYMo7rr6FSQX8VRI87c5Luu6CguC6Lmk7dSNtElMWtBvb1d38ehp5vB7b4b3TtA8VzrPlGDkFM0JFSRThIgZukjpnRApdcHO0YzmeaG4kHPk158hQkrWO-xbvHSDzUzwYfDJJrwBBwnfwQCxt_t12AF-hhS8S_DDNxGc6fDKuBoiHjxeHsWZdc1YW_eGVzvo_aSMJnxdorPWdAmuDnOBXu_XL6uHbPu0eVwtt1mgig6Z1oXQmjUEWqIJ07RoFC-Y0YJXwCtSgakUkcbQtmJ1IznPWUV5wXNFRFMDW6DbX98Q_ccIaSh7m2roOuPAj6ks5N6VCvo_SXMxnZVyIq8P5Fj10JQh2t7Er_KY5gTcHACTatO1cUrFpj-OyamX6dNvhht_Lg</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>SCHTEINGART, David E</creator><creator>BENITEZ, Ricardo</creator><creator>BRADFORD, Carol</creator><creator>NARAYAN, Ajita</creator><creator>SHAOMENG WANG</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20101201</creationdate><title>Expression of Anti-apoptosis Genes Determines the Response of Adrenal Cancer to Apoptosis-inducing Chemotherapy</title><author>SCHTEINGART, David E ; BENITEZ, Ricardo ; BRADFORD, Carol ; NARAYAN, Ajita ; SHAOMENG WANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p272t-9985993d0ef0903928d7483a954be4b0beab706aa2fb3cd64413b24841705dce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adrenal Cortex Neoplasms - drug therapy</topic><topic>Adrenal Cortex Neoplasms - genetics</topic><topic>Adrenal Cortex Neoplasms - metabolism</topic><topic>Adrenal Cortex Neoplasms - pathology</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>bcl-X Protein - biosynthesis</topic><topic>bcl-X Protein - genetics</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Endocrinopathies</topic><topic>Genes, bcl-2</topic><topic>Gossypol - pharmacology</topic><topic>Humans</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Taxoids - pharmacology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHTEINGART, David E</creatorcontrib><creatorcontrib>BENITEZ, Ricardo</creatorcontrib><creatorcontrib>BRADFORD, Carol</creatorcontrib><creatorcontrib>NARAYAN, Ajita</creatorcontrib><creatorcontrib>SHAOMENG WANG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHTEINGART, David E</au><au>BENITEZ, Ricardo</au><au>BRADFORD, Carol</au><au>NARAYAN, Ajita</au><au>SHAOMENG WANG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Anti-apoptosis Genes Determines the Response of Adrenal Cancer to Apoptosis-inducing Chemotherapy</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>30</volume><issue>12</issue><spage>4805</spage><epage>4809</epage><pages>4805-4809</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>This study tested the hypothesis that response of adrenal cortical carcinoma (ACC) to pro-apoptosis drugs depends on expression of anti-apoptosis genes.
Expression of Bcl-2 and Bcl-XL proteins was determined in two human adrenal cancer cell lines, NCI-H-295 and RL-251. Two pro-apoptosis drugs, gossypol (G) and docetaxel (D) were tested in vitro and in vivo in a human ACC/SCID mouse chimera.
Bcl-XL was strongly expressed in RL-251 but not in H-295 and neither expressed the Bcl-2 protein. G and D induced greater dose-dependent inhibition of cell proliferation in RL-251 than in H-295 cells and completely suppressed growth of tumors with high expression of Bcl-XL (p<0.05) while there was no growth suppression in tumors without Bcl-XL expression.
This study provided proof of concept that expression of Bcl-XL determines response to pro-apoptosis drugs. Profiling adrenal tumors for expression of anti-apoptosis genes may provide clues to their potential response to drugs that induce apoptosis.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>21187456</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2010-12, Vol.30 (12), p.4805-4809 |
| issn | 0250-7005 1791-7530 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Adrenal Cortex Neoplasms - drug therapy Adrenal Cortex Neoplasms - genetics Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - pathology Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Animals Apoptosis - drug effects Apoptosis - genetics bcl-X Protein - biosynthesis bcl-X Protein - genetics Biological and medical sciences Cell Line, Tumor Endocrinopathies Genes, bcl-2 Gossypol - pharmacology Humans Malignant tumors Medical sciences Mice Mice, SCID Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Taxoids - pharmacology Tumors |
| title | Expression of Anti-apoptosis Genes Determines the Response of Adrenal Cancer to Apoptosis-inducing Chemotherapy |
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