The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease

Oxidative DNA damage, caused by either endogenous or exogenous sources of reactive oxygen species (ROS), has been linked several diseases including Graves' disease (GD). 7,8‐Dihydro‐8‐oxoguanine (8‐oxoG) is a major lesion produced by ROS and is considered a key biomarker of oxidative DNA damage...

Full description

Saved in:
Bibliographic Details
Published in:Cell biochemistry and function 2011-04, Vol.29 (3), p.244-248
Main Authors: Tanrıkulu, Sevda, Doğru-Abbasoğlu, Semra, Özderya, Ayşenur, Ademoğlu, Evin, Karadağ, Berrin, Erbil, Yeşim, Uysal, Müjdat
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino Acid Substitution
Base excision repair
biomarkers
Biomarkers - analysis
Cysteine - genetics
DNA - analysis
DNA Damage
DNA Glycosylases - genetics
DNA Repair
Female
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Graves Disease - genetics
Graves Disease - physiopathology
Graves' disease
Guanine - analogs & derivatives
Guanine - metabolism
hOGG1
HOGG1 gene
Humans
Male
Middle Aged
N-Glycosylase
Oxidative Stress - genetics
polymorphism
Polymorphism, Genetic
Reactive oxygen species
Reactive Oxygen Species - metabolism
Risk
Serine - genetics
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oxidative DNA damage, caused by either endogenous or exogenous sources of reactive oxygen species (ROS), has been linked several diseases including Graves' disease (GD). 7,8‐Dihydro‐8‐oxoguanine (8‐oxoG) is a major lesion produced by ROS and is considered a key biomarker of oxidative DNA damage. In humans, 8‐oxoG is mainly repaired by 8‐oxoguanine DNA N‐glycosylase‐1 (hOGG1), which is an essential component of the base excision repair (BER) pathway. The functional studies showed that hOGG1 Ser326Cys polymorphism is associated with the reduced DNA repair activity and increased risk for some oxidative stress‐related diseases. In this study, we firstly investigated hOGG1 Ser326Cys polymorphism in GD. According to our results, Cys/Cys genotype frequency in the GD patients (23.4%) was significantly higher than the controls (9.2%). Cys/Cys genotype had an 3.5‐fold [95% CI (confidence interval): 2.10–6.01, p 
ISSN:0263-6484
1099-0844
1099-0844
DOI:10.1002/cbf.1742