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Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation
High thoracic epidural anesthesia (HTEA) blocks the afferent and efferent cardiac sympathetic nerve fibers and may affect atrial electrophysiological characteristics and nerve sprouting in patients with atrial fibrillation (AF). In this study, 18 dogs were randomly divided into a control group ( n ...
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| Published in: | Basic research in cardiology 2011-05, Vol.106 (3), p.495-506 |
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| container_title | Basic research in cardiology |
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| creator | Yang, Shu-sen Han, Wei Cao, Yong Dong, Guo Zhou, Guo Li, Wei-min Gan, Run-tao Chang, Hui-ying Wang, Zheng |
| description | High thoracic epidural anesthesia (HTEA) blocks the afferent and efferent cardiac sympathetic nerve fibers and may affect atrial electrophysiological characteristics and nerve sprouting in patients with atrial fibrillation (AF). In this study, 18 dogs were randomly divided into a control group (
n
= 6), in which dogs were atrially paced at 400 beats/min for 6 weeks; an HTEA group (
n
= 6), in which dogs underwent atrial pacing and HTEA for 6 weeks; and a sham-operated group (
n
= 6), in which dogs underwent the operation but did not receive atrial pacing or HTEA. Electrophysiological examinations were performed in all groups. Cardiac nerves were immunocytochemically stained with anti-growth-associated protein 43 (GAP43) and anti-tyrosine hydroxylase (TH) antibodies. The protein expressions of nerve growth factor (NGF), GAP43 and TH in atrial myocardium were also studied by western blot. In addition, the plasma levels of C-reactive protein (CRP) and norepinephrine, as well as atrial production of superoxide anion (O
2
·−
) and malondialdehyde, were measured. In the HTEA group, atrial effective refractory period increased (
P
|
| doi_str_mv | 10.1007/s00395-011-0154-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860880265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1758246241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-2454b2fb3bfbf2976bd0018076caf986fcdb6a0ac77fb4bc8c32c7e396acb2d23</originalsourceid><addsrcrecordid>eNp9kcuq1TAUhoMonu3RB3AiwYlOqiuXpulQDscLHHCi45KkyW4ObVOTVtjv44O6yt4qCDoIgcX3_-vyE_KcwRsG0LwtAKKtK2AMXy0r8YAcmBR1xTSIh-QAAqDSkusr8qSUewAmlWKPyRVngmneqgP5cRuCd2uhKdAhHge6DikbFx31S-y3bEZqZl_WwZdoaJqpWXPEoh9RldMynEpMYzpGh0U3GNSuPseyRldQ2dNymhaDcizQ2efvnpYlp22N85FGtKPOzHH2dEq9H_cpLg1CtDmOo1ljmp-SR8GMxT-7_Nfk6_vbLzcfq7vPHz7dvLurnASxVlzW0vJghQ028LZRtseVNTTKmdBqFVxvlQHjmiZYaZ12grvGi1YZZ3nPxTV5dfbFCb9tuHU3xeI8TjH7tJVOK9AauKqRfP1fkjW15lJxyRB9-Rd6n7Y84x67H98RQIidIZdTKdmHbslxMvnUMej2rLtz1h1m3e1ZdwI1Ly7Gm518_1vxK1wE-BnAi-O5ff7T-d-uPwEF3bh6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>860224130</pqid></control><display><type>article</type><title>Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation</title><source>Springer Link</source><creator>Yang, Shu-sen ; Han, Wei ; Cao, Yong ; Dong, Guo ; Zhou, Guo ; Li, Wei-min ; Gan, Run-tao ; Chang, Hui-ying ; Wang, Zheng</creator><creatorcontrib>Yang, Shu-sen ; Han, Wei ; Cao, Yong ; Dong, Guo ; Zhou, Guo ; Li, Wei-min ; Gan, Run-tao ; Chang, Hui-ying ; Wang, Zheng</creatorcontrib><description>High thoracic epidural anesthesia (HTEA) blocks the afferent and efferent cardiac sympathetic nerve fibers and may affect atrial electrophysiological characteristics and nerve sprouting in patients with atrial fibrillation (AF). In this study, 18 dogs were randomly divided into a control group (
n
= 6), in which dogs were atrially paced at 400 beats/min for 6 weeks; an HTEA group (
n
= 6), in which dogs underwent atrial pacing and HTEA for 6 weeks; and a sham-operated group (
n
= 6), in which dogs underwent the operation but did not receive atrial pacing or HTEA. Electrophysiological examinations were performed in all groups. Cardiac nerves were immunocytochemically stained with anti-growth-associated protein 43 (GAP43) and anti-tyrosine hydroxylase (TH) antibodies. The protein expressions of nerve growth factor (NGF), GAP43 and TH in atrial myocardium were also studied by western blot. In addition, the plasma levels of C-reactive protein (CRP) and norepinephrine, as well as atrial production of superoxide anion (O
2
·−
) and malondialdehyde, were measured. In the HTEA group, atrial effective refractory period increased (
P
< 0.05) and AF maintenance decreased (
P
< 0.01) significantly compared with the control group. The densities of GAP43-positive nerves and TH-positive nerves were significantly lower in the HTEA group compared with the control group. The protein levels of NGF, GAP43 and TH were also lower in the HTEA group compared with the control group. A significant positive correlation between the expressions of NGF and GAP43 (
P
< 0.01) was observed. A similar correlation was demonstrated for NGF and TH (
P
< 0.01) in our study. Furthermore, the plasma levels of CRP and norepinephrine, as well as the amount of O
2
·−
and malondialdehyde produced from myocardium, decreased in the HTEA group compared with the control group. In conclusion, HTEA inhibited electrical and nerve remodeling and reduced the maintenance of AF in a canine AF model, in which process HTEA exhibited anti-inflammatory and antioxidant effects, indicating that, in addition to the efferent cardiac sympathetic nerve, afferent fibers also play an important role in the initiation and/or maintenance of AF.</description><identifier>ISSN: 0300-8428</identifier><identifier>EISSN: 1435-1803</identifier><identifier>DOI: 10.1007/s00395-011-0154-3</identifier><identifier>PMID: 21318296</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Anesthesia, Epidural ; Animals ; Atrial Fibrillation - metabolism ; Atrial Fibrillation - physiopathology ; Autonomic Pathways - metabolism ; Autonomic Pathways - physiopathology ; Blotting, Western ; Cardiology ; Dogs ; Electrophysiology ; Heart Atria - innervation ; Immunohistochemistry ; Medicine ; Medicine & Public Health ; Nerve Regeneration - physiology ; Neurons, Afferent - cytology ; Neurons, Afferent - metabolism ; Original Contribution ; Sympathetic Nervous System - metabolism ; Sympathetic Nervous System - physiopathology ; Thoracic Vertebrae ; Ventricular Remodeling - physiology</subject><ispartof>Basic research in cardiology, 2011-05, Vol.106 (3), p.495-506</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-2454b2fb3bfbf2976bd0018076caf986fcdb6a0ac77fb4bc8c32c7e396acb2d23</citedby><cites>FETCH-LOGICAL-c403t-2454b2fb3bfbf2976bd0018076caf986fcdb6a0ac77fb4bc8c32c7e396acb2d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21318296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Shu-sen</creatorcontrib><creatorcontrib>Han, Wei</creatorcontrib><creatorcontrib>Cao, Yong</creatorcontrib><creatorcontrib>Dong, Guo</creatorcontrib><creatorcontrib>Zhou, Guo</creatorcontrib><creatorcontrib>Li, Wei-min</creatorcontrib><creatorcontrib>Gan, Run-tao</creatorcontrib><creatorcontrib>Chang, Hui-ying</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><title>Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation</title><title>Basic research in cardiology</title><addtitle>Basic Res Cardiol</addtitle><addtitle>Basic Res Cardiol</addtitle><description>High thoracic epidural anesthesia (HTEA) blocks the afferent and efferent cardiac sympathetic nerve fibers and may affect atrial electrophysiological characteristics and nerve sprouting in patients with atrial fibrillation (AF). In this study, 18 dogs were randomly divided into a control group (
n
= 6), in which dogs were atrially paced at 400 beats/min for 6 weeks; an HTEA group (
n
= 6), in which dogs underwent atrial pacing and HTEA for 6 weeks; and a sham-operated group (
n
= 6), in which dogs underwent the operation but did not receive atrial pacing or HTEA. Electrophysiological examinations were performed in all groups. Cardiac nerves were immunocytochemically stained with anti-growth-associated protein 43 (GAP43) and anti-tyrosine hydroxylase (TH) antibodies. The protein expressions of nerve growth factor (NGF), GAP43 and TH in atrial myocardium were also studied by western blot. In addition, the plasma levels of C-reactive protein (CRP) and norepinephrine, as well as atrial production of superoxide anion (O
2
·−
) and malondialdehyde, were measured. In the HTEA group, atrial effective refractory period increased (
P
< 0.05) and AF maintenance decreased (
P
< 0.01) significantly compared with the control group. The densities of GAP43-positive nerves and TH-positive nerves were significantly lower in the HTEA group compared with the control group. The protein levels of NGF, GAP43 and TH were also lower in the HTEA group compared with the control group. A significant positive correlation between the expressions of NGF and GAP43 (
P
< 0.01) was observed. A similar correlation was demonstrated for NGF and TH (
P
< 0.01) in our study. Furthermore, the plasma levels of CRP and norepinephrine, as well as the amount of O
2
·−
and malondialdehyde produced from myocardium, decreased in the HTEA group compared with the control group. In conclusion, HTEA inhibited electrical and nerve remodeling and reduced the maintenance of AF in a canine AF model, in which process HTEA exhibited anti-inflammatory and antioxidant effects, indicating that, in addition to the efferent cardiac sympathetic nerve, afferent fibers also play an important role in the initiation and/or maintenance of AF.</description><subject>Anesthesia, Epidural</subject><subject>Animals</subject><subject>Atrial Fibrillation - metabolism</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Autonomic Pathways - metabolism</subject><subject>Autonomic Pathways - physiopathology</subject><subject>Blotting, Western</subject><subject>Cardiology</subject><subject>Dogs</subject><subject>Electrophysiology</subject><subject>Heart Atria - innervation</subject><subject>Immunohistochemistry</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerve Regeneration - physiology</subject><subject>Neurons, Afferent - cytology</subject><subject>Neurons, Afferent - metabolism</subject><subject>Original Contribution</subject><subject>Sympathetic Nervous System - metabolism</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Thoracic Vertebrae</subject><subject>Ventricular Remodeling - physiology</subject><issn>0300-8428</issn><issn>1435-1803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kcuq1TAUhoMonu3RB3AiwYlOqiuXpulQDscLHHCi45KkyW4ObVOTVtjv44O6yt4qCDoIgcX3_-vyE_KcwRsG0LwtAKKtK2AMXy0r8YAcmBR1xTSIh-QAAqDSkusr8qSUewAmlWKPyRVngmneqgP5cRuCd2uhKdAhHge6DikbFx31S-y3bEZqZl_WwZdoaJqpWXPEoh9RldMynEpMYzpGh0U3GNSuPseyRldQ2dNymhaDcizQ2efvnpYlp22N85FGtKPOzHH2dEq9H_cpLg1CtDmOo1ljmp-SR8GMxT-7_Nfk6_vbLzcfq7vPHz7dvLurnASxVlzW0vJghQ028LZRtseVNTTKmdBqFVxvlQHjmiZYaZ12grvGi1YZZ3nPxTV5dfbFCb9tuHU3xeI8TjH7tJVOK9AauKqRfP1fkjW15lJxyRB9-Rd6n7Y84x67H98RQIidIZdTKdmHbslxMvnUMej2rLtz1h1m3e1ZdwI1Ly7Gm518_1vxK1wE-BnAi-O5ff7T-d-uPwEF3bh6</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Yang, Shu-sen</creator><creator>Han, Wei</creator><creator>Cao, Yong</creator><creator>Dong, Guo</creator><creator>Zhou, Guo</creator><creator>Li, Wei-min</creator><creator>Gan, Run-tao</creator><creator>Chang, Hui-ying</creator><creator>Wang, Zheng</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation</title><author>Yang, Shu-sen ; Han, Wei ; Cao, Yong ; Dong, Guo ; Zhou, Guo ; Li, Wei-min ; Gan, Run-tao ; Chang, Hui-ying ; Wang, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-2454b2fb3bfbf2976bd0018076caf986fcdb6a0ac77fb4bc8c32c7e396acb2d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anesthesia, Epidural</topic><topic>Animals</topic><topic>Atrial Fibrillation - metabolism</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Autonomic Pathways - metabolism</topic><topic>Autonomic Pathways - physiopathology</topic><topic>Blotting, Western</topic><topic>Cardiology</topic><topic>Dogs</topic><topic>Electrophysiology</topic><topic>Heart Atria - innervation</topic><topic>Immunohistochemistry</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nerve Regeneration - physiology</topic><topic>Neurons, Afferent - cytology</topic><topic>Neurons, Afferent - metabolism</topic><topic>Original Contribution</topic><topic>Sympathetic Nervous System - metabolism</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Thoracic Vertebrae</topic><topic>Ventricular Remodeling - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shu-sen</creatorcontrib><creatorcontrib>Han, Wei</creatorcontrib><creatorcontrib>Cao, Yong</creatorcontrib><creatorcontrib>Dong, Guo</creatorcontrib><creatorcontrib>Zhou, Guo</creatorcontrib><creatorcontrib>Li, Wei-min</creatorcontrib><creatorcontrib>Gan, Run-tao</creatorcontrib><creatorcontrib>Chang, Hui-ying</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Basic research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shu-sen</au><au>Han, Wei</au><au>Cao, Yong</au><au>Dong, Guo</au><au>Zhou, Guo</au><au>Li, Wei-min</au><au>Gan, Run-tao</au><au>Chang, Hui-ying</au><au>Wang, Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation</atitle><jtitle>Basic research in cardiology</jtitle><stitle>Basic Res Cardiol</stitle><addtitle>Basic Res Cardiol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>106</volume><issue>3</issue><spage>495</spage><epage>506</epage><pages>495-506</pages><issn>0300-8428</issn><eissn>1435-1803</eissn><abstract>High thoracic epidural anesthesia (HTEA) blocks the afferent and efferent cardiac sympathetic nerve fibers and may affect atrial electrophysiological characteristics and nerve sprouting in patients with atrial fibrillation (AF). In this study, 18 dogs were randomly divided into a control group (
n
= 6), in which dogs were atrially paced at 400 beats/min for 6 weeks; an HTEA group (
n
= 6), in which dogs underwent atrial pacing and HTEA for 6 weeks; and a sham-operated group (
n
= 6), in which dogs underwent the operation but did not receive atrial pacing or HTEA. Electrophysiological examinations were performed in all groups. Cardiac nerves were immunocytochemically stained with anti-growth-associated protein 43 (GAP43) and anti-tyrosine hydroxylase (TH) antibodies. The protein expressions of nerve growth factor (NGF), GAP43 and TH in atrial myocardium were also studied by western blot. In addition, the plasma levels of C-reactive protein (CRP) and norepinephrine, as well as atrial production of superoxide anion (O
2
·−
) and malondialdehyde, were measured. In the HTEA group, atrial effective refractory period increased (
P
< 0.05) and AF maintenance decreased (
P
< 0.01) significantly compared with the control group. The densities of GAP43-positive nerves and TH-positive nerves were significantly lower in the HTEA group compared with the control group. The protein levels of NGF, GAP43 and TH were also lower in the HTEA group compared with the control group. A significant positive correlation between the expressions of NGF and GAP43 (
P
< 0.01) was observed. A similar correlation was demonstrated for NGF and TH (
P
< 0.01) in our study. Furthermore, the plasma levels of CRP and norepinephrine, as well as the amount of O
2
·−
and malondialdehyde produced from myocardium, decreased in the HTEA group compared with the control group. In conclusion, HTEA inhibited electrical and nerve remodeling and reduced the maintenance of AF in a canine AF model, in which process HTEA exhibited anti-inflammatory and antioxidant effects, indicating that, in addition to the efferent cardiac sympathetic nerve, afferent fibers also play an important role in the initiation and/or maintenance of AF.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21318296</pmid><doi>10.1007/s00395-011-0154-3</doi><tpages>12</tpages></addata></record> |
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| ispartof | Basic research in cardiology, 2011-05, Vol.106 (3), p.495-506 |
| issn | 0300-8428 1435-1803 |
| language | eng |
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| subjects | Anesthesia, Epidural Animals Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology Autonomic Pathways - metabolism Autonomic Pathways - physiopathology Blotting, Western Cardiology Dogs Electrophysiology Heart Atria - innervation Immunohistochemistry Medicine Medicine & Public Health Nerve Regeneration - physiology Neurons, Afferent - cytology Neurons, Afferent - metabolism Original Contribution Sympathetic Nervous System - metabolism Sympathetic Nervous System - physiopathology Thoracic Vertebrae Ventricular Remodeling - physiology |
| title | Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation |
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