Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes

Summary Objective  There is a high prevalence of low testosterone and dyslipidaemia in men with type 2 diabetes. The androgen receptor CAG repeat polymorphism (AR CAG) affects receptor transcriptional activity (the shorter repeats the more sensitive AR) and is associated with androgenic parameters a...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2011-05, Vol.74 (5), p.624-630
Main Authors: Stanworth, R. D., Kapoor, D., Channer, K. S., Jones, T. H.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cholesterol, HDL - blood
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Dyslipidemias - etiology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Estradiol - blood
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Receptors, Androgen - genetics
Testosterone - blood
Trinucleotide Repeats
Vertebrates: endocrinology
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Summary:Summary Objective  There is a high prevalence of low testosterone and dyslipidaemia in men with type 2 diabetes. The androgen receptor CAG repeat polymorphism (AR CAG) affects receptor transcriptional activity (the shorter repeats the more sensitive AR) and is associated with androgenic parameters and obesity. This study describes the relationships between testosterone, AR CAG and serum lipids in men with type 2 diabetes. Design and Patients  Cross‐sectional study of men with type 2 diabetes in a District General Hospital Diabetes Centre. Measurements  Correlation between testosterone, AR CAG and serum lipids. Results  HDL cholesterol (HDL‐C) correlated with total testosterone (TT) (r = 0·251, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2011.03969.x