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A Combined Desorption Ionization by Charge Exchange (DICE) and Desorption Electrospray Ionization (DESI) Source for Mass Spectrometry

A source that couples the desorption ionization by charge exchange (DICE) and desorption electrospray ionization (DESI) techniques together was demonstrated to broaden the range of compounds that can be analyzed in a single mass spectrometric experiment under ambient conditions. A tee union was used...

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Published in:Journal of the American Society for Mass Spectrometry 2011, Vol.22 (1), p.173-178
Main Authors: Chan, Chang-Ching, Bolgar, Mark S., Miller, Scott A., Attygalle, Athula B.
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Language:English
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cited_by cdi_FETCH-LOGICAL-c416t-5cf44a88f1d05796f9b0677d571cac90c25d50b6b71f796eb4a9297b3b3ca7c3
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container_title Journal of the American Society for Mass Spectrometry
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creator Chan, Chang-Ching
Bolgar, Mark S.
Miller, Scott A.
Attygalle, Athula B.
description A source that couples the desorption ionization by charge exchange (DICE) and desorption electrospray ionization (DESI) techniques together was demonstrated to broaden the range of compounds that can be analyzed in a single mass spectrometric experiment under ambient conditions. A tee union was used to mix the spray reagents into a partially immiscible blend before this mixture was passed through a conventional electrospray (ES) probe capillary. Using this technique, compounds that are ionized more efficiently by the DICE method and those that are ionized better with the DESI procedure could be analyzed simultaneously. For example, hydroquinone, which is not detected when subjected to DESI-MS in the positive-ion generation mode, or the sodium adduct of guaifenesin, which is not detected when examined by DICE-MS, could both be detected in one experiment when the two techniques were combined. The combined technique was able to generate the molecular ion, proton and metal adduct from the same compound. When coupled to a tandem mass spectrometer, the combined source enabled the generation of product ion spectra from the molecular ion and the [M + H] + or [M + metal] + ions of the same compound without the need to physically change the source from DICE to DESI. The ability to record CID spectra of both the molecular ion and adduct ions in a single mass spectrometric experiment adds a new dimension to the array of mass spectrometric methods available for structural studies.
doi_str_mv 10.1007/s13361-010-0001-z
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Acetaminophen - analysis
Acetaminophen - chemistry
Analysis
Analytical Chemistry
Bioinformatics
Biological and medical sciences
Biotechnology
Caffeine - analysis
Caffeine - chemistry
Chemistry
Chemistry and Materials Science
Exact sciences and technology
General pharmacology
Ibuprofen - analysis
Ibuprofen - chemistry
Mass spectrometry
Medical sciences
Organic Chemistry
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - chemistry
Pharmacology. Drug treatments
Pressure
Proteomics
Reactivity and mechanisms
Research Article
Spectrometry, Mass, Electrospray Ionization - methods
title A Combined Desorption Ionization by Charge Exchange (DICE) and Desorption Electrospray Ionization (DESI) Source for Mass Spectrometry
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