Hepatitis C virus (HCV) treatment uptake and changes in the prevalence of HCV genotypes in HIV/HCV-coinfected patients

The efficacy of current hepatitis C therapy in HIV/HCV‐coinfected patients is largely dependent on HCV genotype. The annual prevalence of HCV genotypes/subtypes and their influence on HCV clearance with antiviral treatment were examined in a dynamic cohort of HIV/HCV‐coinfected patients followed up...

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Bibliographic Details
Published in:Journal of viral hepatitis 2011-05, Vol.18 (5), p.325-330
Main Authors: Medrano, J., Resino, S., Vispo, E., Madejón, A., Labarga, P., Tuma, P., Martín-Carbonero, L., Barreiro, P., Rodriguez-Novoa, S., Jiménez-Nacher, I., Soriano, V.
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Cohort Studies
Drug Therapy, Combination - trends
Follow-Up Studies
Genotype
HCV genotypes
Hepacivirus - classification
Hepacivirus - drug effects
Hepacivirus - genetics
hepatitis C
Hepatitis C - complications
Hepatitis C - drug therapy
Hepatitis C - epidemiology
Hepatitis C - virology
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV Seropositivity
Humans
Incidence
Interferons - therapeutic use
Male
pegylated interferon
Population Dynamics
Prevalence
Ribavirin - therapeutic use
RNA, Viral - blood
RNA, Viral - genetics
Substance Abuse, Intravenous
treatment uptake
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Summary:The efficacy of current hepatitis C therapy in HIV/HCV‐coinfected patients is largely dependent on HCV genotype. The annual prevalence of HCV genotypes/subtypes and their influence on HCV clearance with antiviral treatment were examined in a dynamic cohort of HIV/HCV‐coinfected patients followed up in Madrid since 2000. Patients entered the cohort at first visit and left the cohort when HCV clearance was achieved with HCV therapy or when follow‐up was interrupted for any reason, including death. A total of 672 HIV/HCV‐coinfected patients constituted the cohort. The mean follow‐up time was 5.5 years, corresponding to 4108 patient‐years. Mean age at entry was 37 years, and 73% were men and 86% were intravenous drug users. Overall distribution of HCV genotypes was as follows: 57.1% HCV‐1 (1a: 29.2%, 1b: 20.4%, unknown: 7.6%), 1.3% HCV‐2, 25.4% HCV‐3 and 15.9% HCV‐4. A total of 274 (40.8%) patients were treated with peginterferon–ribavirin, of whom 116 (42.3%) achieved HCV clearance following 1–3 courses of therapy. The proportion of HCV‐1/4 rose from 71.7% in 2000 to 76.8% in 2008, whereas the proportion of HCV‐2/3 fell from 28.1% in 2000 to 23.2% in 2008. The yearly prevalence increased for HCV‐1 (R2: 0.92, b: 0.59, P 
ISSN:1352-0504
1365-2893
DOI:10.1111/j.1365-2893.2010.01309.x