Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes

• Published in: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2010, Vol.56 (6), p.93-99
• Main Authors: Hurina, N M, Korpacheva-Zinych, O V, Shuprovych, A A
• Format: Article
• Language: Ukrainian
• Subjects: Aged; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - urine; Humans; Insulin - blood; Insulin Resistance; Male; Middle Aged; Testosterone - blood; Uric Acid - blood; Uric Acid - metabolism; Uric Acid - urine
• ISSN: 2522-9028

95 men aged 45-65, suffering from type 2 diabetes for 0.1-20 years (4.5 +/- 1.4) were examined. Hypoandrogenia (serum testosterone < 10,4 nmol/ml) was noted in 37% of investigated patients. Hyperuricemia (HUA), defined by serum uric acid (UA) content more than 450 pmol/L, was detected in 34% of subjects. In 74% of patients there was a high level of 24h UA urine excretion (UA(u) > 4.43 mmol), suggesting a hyperproduction of UA. Because the level of uricemia is defined by UA production and extretion, we outline two main types of alterations in UA metabolism: normouricemic, hyperuricosuric and hyperuricemic. In normouricemic and hyperuricosuric men UA excretion growth in parallel with the rate of kidney filtration, obesity, glycemia. High urate elimination index (UEI) suggests a decrease of UA reabsorption in kidney. The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome.