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Determination of isometamidium residues in animal-derived foods by liquid chromatography–tandem mass spectrometry
In this paper, a new determination method for isometamidium residues in animal-derived foods was developed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Isometamidium residues in bovine tissues and milk were extracted with the mixed solution of acetonitrile and 0.25 mol/L of ammonium...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-04, Vol.879 (13), p.1008-1012 |
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| cited_by | cdi_FETCH-LOGICAL-c451t-d48b24a6d692ad854913cbd2999ddf9b2949613eb23576557a5eb96c28df2b393 |
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| cites | cdi_FETCH-LOGICAL-c451t-d48b24a6d692ad854913cbd2999ddf9b2949613eb23576557a5eb96c28df2b393 |
| container_end_page | 1012 |
| container_issue | 13 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Li, Y.G. Zou, Y. Zhang, L. Xi, C.X. Wang, G.M. Li, X.L. Zhang, J.Z. Li, Z.G. |
| description | In this paper, a new determination method for isometamidium residues in animal-derived foods was developed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Isometamidium residues in bovine tissues and milk were extracted with the mixed solution of acetonitrile and 0.25
mol/L of ammonium formate–methanol (v/v, 1:1), concentrated and degreased, and determined by LC–MS/MS with quantification by external standard method. The results showed that the peak area of chromatogram was linearly related to the concentration of isometamidium in the range of 1–100
μg/L, and the limits of detection (LOD) and quantification (LOQ) were 0.05
μg/kg and 5
μg/kg, respectively. The average recoveries of spiked samples were in the range of 73.8–93.9% with relative standard deviations ranged from 2.3% to 7.5%. This method is simple, accurate and suitable for the identification and quantification for isometamidium in animal-derived foods. |
| doi_str_mv | 10.1016/j.jchromb.2011.02.040 |
| format | article |
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mol/L of ammonium formate–methanol (v/v, 1:1), concentrated and degreased, and determined by LC–MS/MS with quantification by external standard method. The results showed that the peak area of chromatogram was linearly related to the concentration of isometamidium in the range of 1–100
μg/L, and the limits of detection (LOD) and quantification (LOQ) were 0.05
μg/kg and 5
μg/kg, respectively. The average recoveries of spiked samples were in the range of 73.8–93.9% with relative standard deviations ranged from 2.3% to 7.5%. This method is simple, accurate and suitable for the identification and quantification for isometamidium in animal-derived foods.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2011.02.040</identifier><identifier>PMID: 21419723</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acetonitrile ; Analysis ; Analytical, structural and metabolic biochemistry ; Animal-derived food ; Animals ; Biological and medical sciences ; Cattle ; Chromatography ; Chromatography, High Pressure Liquid - methods ; detection limit ; Drug Residues - analysis ; Foods ; Formates ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; HPLC–MS/MS ; Isometamidium ; Linear Models ; liquid chromatography ; Liquids ; Liver ; Mass spectrometry ; Meat - analysis ; Medical sciences ; Methanol ; milk ; Milk - chemistry ; Pharmacology. Drug treatments ; Phenanthridines - analysis ; Phenanthridines - chemistry ; Reproducibility of Results ; Residual detection ; Residues ; Sensitivity and Specificity ; Standard deviation ; tandem mass spectrometry ; Tandem Mass Spectrometry - methods ; tissues ; Trypanocidal Agents - analysis ; Trypanocidal Agents - chemistry</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-04, Vol.879 (13), p.1008-1012</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-d48b24a6d692ad854913cbd2999ddf9b2949613eb23576557a5eb96c28df2b393</citedby><cites>FETCH-LOGICAL-c451t-d48b24a6d692ad854913cbd2999ddf9b2949613eb23576557a5eb96c28df2b393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24045838$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21419723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Y.G.</creatorcontrib><creatorcontrib>Zou, Y.</creatorcontrib><creatorcontrib>Zhang, L.</creatorcontrib><creatorcontrib>Xi, C.X.</creatorcontrib><creatorcontrib>Wang, G.M.</creatorcontrib><creatorcontrib>Li, X.L.</creatorcontrib><creatorcontrib>Zhang, J.Z.</creatorcontrib><creatorcontrib>Li, Z.G.</creatorcontrib><title>Determination of isometamidium residues in animal-derived foods by liquid chromatography–tandem mass spectrometry</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>In this paper, a new determination method for isometamidium residues in animal-derived foods was developed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Isometamidium residues in bovine tissues and milk were extracted with the mixed solution of acetonitrile and 0.25
mol/L of ammonium formate–methanol (v/v, 1:1), concentrated and degreased, and determined by LC–MS/MS with quantification by external standard method. The results showed that the peak area of chromatogram was linearly related to the concentration of isometamidium in the range of 1–100
μg/L, and the limits of detection (LOD) and quantification (LOQ) were 0.05
μg/kg and 5
μg/kg, respectively. The average recoveries of spiked samples were in the range of 73.8–93.9% with relative standard deviations ranged from 2.3% to 7.5%. This method is simple, accurate and suitable for the identification and quantification for isometamidium in animal-derived foods.</description><subject>Acetonitrile</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animal-derived food</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>detection limit</subject><subject>Drug Residues - analysis</subject><subject>Foods</subject><subject>Formates</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>HPLC–MS/MS</subject><subject>Isometamidium</subject><subject>Linear Models</subject><subject>liquid chromatography</subject><subject>Liquids</subject><subject>Liver</subject><subject>Mass spectrometry</subject><subject>Meat - analysis</subject><subject>Medical sciences</subject><subject>Methanol</subject><subject>milk</subject><subject>Milk - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenanthridines - analysis</subject><subject>Phenanthridines - chemistry</subject><subject>Reproducibility of Results</subject><subject>Residual detection</subject><subject>Residues</subject><subject>Sensitivity and Specificity</subject><subject>Standard deviation</subject><subject>tandem mass spectrometry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>tissues</subject><subject>Trypanocidal Agents - analysis</subject><subject>Trypanocidal Agents - chemistry</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1DAUhiMEoqXwCIA3CDYJvjteIVSuUiUWUImd5dgnrUdxPLWTSrPjHXhDngQPM8AOVvbiO_-5fE3zmOCOYCJfbrqNu84pDh3FhHSYdpjjO80p6RVrmZJf79a_ULjFlNGT5kEpG4yJwordb04o4UQryk6b8gYWyDHMdglpRmlEoaQIi43BhzWiDCX4FQoKM7JziHZqPeRwCx6NKfmChh2aws0aPPo1jl3SVbbb692Pb98XO3uIKNpSUNmCW_I-Oe8eNvdGOxV4dHzPmst3b7-cf2gvPr3_eP76onVckKX1vB8ot9JLTa3vBdeEucFTrbX3ox6o5loSBgNlQkkhlBUwaOlo70c6MM3OmueH3G1ON3WHxcRQHEyTnSGtxfSSiF72BFfyxT9JIhXhmPZ0HyoOqMuplAyj2eZ6lrwzBJu9GbMxRzNmb8ZgaqqZWvfk2GIdIvg_Vb9VVODZEbDF2WnMdnah_OU45qJnfeWeHrjRJmOvcmUuP9dOEmMsBVWiEq8OBNTj3gbIprgAswMfcrVgfAr_GfYnszC7Cw</recordid><startdate>20110415</startdate><enddate>20110415</enddate><creator>Li, Y.G.</creator><creator>Zou, Y.</creator><creator>Zhang, L.</creator><creator>Xi, C.X.</creator><creator>Wang, G.M.</creator><creator>Li, X.L.</creator><creator>Zhang, J.Z.</creator><creator>Li, Z.G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>7X8</scope></search><sort><creationdate>20110415</creationdate><title>Determination of isometamidium residues in animal-derived foods by liquid chromatography–tandem mass spectrometry</title><author>Li, Y.G. ; Zou, Y. ; Zhang, L. ; Xi, C.X. ; Wang, G.M. ; Li, X.L. ; Zhang, J.Z. ; Li, Z.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-d48b24a6d692ad854913cbd2999ddf9b2949613eb23576557a5eb96c28df2b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetonitrile</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animal-derived food</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>detection limit</topic><topic>Drug Residues - analysis</topic><topic>Foods</topic><topic>Formates</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>HPLC–MS/MS</topic><topic>Isometamidium</topic><topic>Linear Models</topic><topic>liquid chromatography</topic><topic>Liquids</topic><topic>Liver</topic><topic>Mass spectrometry</topic><topic>Meat - analysis</topic><topic>Medical sciences</topic><topic>Methanol</topic><topic>milk</topic><topic>Milk - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenanthridines - analysis</topic><topic>Phenanthridines - chemistry</topic><topic>Reproducibility of Results</topic><topic>Residual detection</topic><topic>Residues</topic><topic>Sensitivity and Specificity</topic><topic>Standard deviation</topic><topic>tandem mass spectrometry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>tissues</topic><topic>Trypanocidal Agents - analysis</topic><topic>Trypanocidal Agents - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Y.G.</creatorcontrib><creatorcontrib>Zou, Y.</creatorcontrib><creatorcontrib>Zhang, L.</creatorcontrib><creatorcontrib>Xi, C.X.</creatorcontrib><creatorcontrib>Wang, G.M.</creatorcontrib><creatorcontrib>Li, X.L.</creatorcontrib><creatorcontrib>Zhang, J.Z.</creatorcontrib><creatorcontrib>Li, Z.G.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Y.G.</au><au>Zou, Y.</au><au>Zhang, L.</au><au>Xi, C.X.</au><au>Wang, G.M.</au><au>Li, X.L.</au><au>Zhang, J.Z.</au><au>Li, Z.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of isometamidium residues in animal-derived foods by liquid chromatography–tandem mass spectrometry</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2011-04-15</date><risdate>2011</risdate><volume>879</volume><issue>13</issue><spage>1008</spage><epage>1012</epage><pages>1008-1012</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>In this paper, a new determination method for isometamidium residues in animal-derived foods was developed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Isometamidium residues in bovine tissues and milk were extracted with the mixed solution of acetonitrile and 0.25
mol/L of ammonium formate–methanol (v/v, 1:1), concentrated and degreased, and determined by LC–MS/MS with quantification by external standard method. The results showed that the peak area of chromatogram was linearly related to the concentration of isometamidium in the range of 1–100
μg/L, and the limits of detection (LOD) and quantification (LOQ) were 0.05
μg/kg and 5
μg/kg, respectively. The average recoveries of spiked samples were in the range of 73.8–93.9% with relative standard deviations ranged from 2.3% to 7.5%. This method is simple, accurate and suitable for the identification and quantification for isometamidium in animal-derived foods.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21419723</pmid><doi>10.1016/j.jchromb.2011.02.040</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-04, Vol.879 (13), p.1008-1012 |
| issn | 1570-0232 1873-376X |
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| source | Elsevier |
| subjects | Acetonitrile Analysis Analytical, structural and metabolic biochemistry Animal-derived food Animals Biological and medical sciences Cattle Chromatography Chromatography, High Pressure Liquid - methods detection limit Drug Residues - analysis Foods Formates Fundamental and applied biological sciences. Psychology General pharmacology HPLC–MS/MS Isometamidium Linear Models liquid chromatography Liquids Liver Mass spectrometry Meat - analysis Medical sciences Methanol milk Milk - chemistry Pharmacology. Drug treatments Phenanthridines - analysis Phenanthridines - chemistry Reproducibility of Results Residual detection Residues Sensitivity and Specificity Standard deviation tandem mass spectrometry Tandem Mass Spectrometry - methods tissues Trypanocidal Agents - analysis Trypanocidal Agents - chemistry |
| title | Determination of isometamidium residues in animal-derived foods by liquid chromatography–tandem mass spectrometry |
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