Enhanced complement consumption in neuromyelitis optica and Behçet's disease patients

Abstract The complement system is essential in the pathogenesis of inflammatory central nervous system disorders. To investigate the involvement of complement pathways in neuromyelitis optica (NMO), levels of breakdown products for classical (C4d), alternative (FBb) and common (sC5b-9) pathways were...

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Bibliographic Details
Published in:Journal of neuroimmunology 2011-04, Vol.233 (1), p.211-215
Main Authors: Tüzün, Erdem, Kürtüncü, Murat, Türkoğlu, Recai, İçöz, Sema, Pehlivan, Münevver, Birişik, Ömer, Eraksoy, Mefküre, Akman-Demir, Gulsen
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergy and Immunology
Behcet Syndrome - diagnosis
Behcet Syndrome - immunology
Behcet Syndrome - pathology
Behçet's disease
Complement
Complement Activation - immunology
Disability
Female
Humans
Male
Middle Aged
Multiple sclerosis
Neurology
Neuromyelitis optica
Neuromyelitis Optica - diagnosis
Neuromyelitis Optica - immunology
Neuromyelitis Optica - pathology
Up-Regulation - immunology
Young Adult
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Summary:Abstract The complement system is essential in the pathogenesis of inflammatory central nervous system disorders. To investigate the involvement of complement pathways in neuromyelitis optica (NMO), levels of breakdown products for classical (C4d), alternative (FBb) and common (sC5b-9) pathways were measured in the sera of 28 NMO and control patients (30 Behçet's disease (BD), 29 multiple sclerosis (MS)) and 31 healthy controls by ELISA. Classical and/or alternative pathway consumption was enhanced in NMO and BD patients as compared to MS patients and healthy controls. Our results suggest that NBD and NMO differ from MS by the predominance of complement system involvement.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2010.11.010