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Direct-injection HPLC method of measuring micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column
A direct-injection HPLC-based method has been developed for determining amounts of micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column. The method is easy to perform and requires only 10 μL of a filtered plasma sample. The chromatographic separations were carried out w...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-04, Vol.879 (13), p.1029-1032 |
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| cited_by | cdi_FETCH-LOGICAL-c517t-5796f4d5544f8f88097d3ddab60832d6dac84f4b5c844cb04e42198973d95bd13 |
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| cites | cdi_FETCH-LOGICAL-c517t-5796f4d5544f8f88097d3ddab60832d6dac84f4b5c844cb04e42198973d95bd13 |
| container_end_page | 1032 |
| container_issue | 13 |
| container_start_page | 1029 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 879 |
| creator | Uranishi, Hiroaki Nakamura, Mitsuhiro Nakamura, Hiroki Ikeda, Yukari Otsuka, Mayuko Kato, Zenichiro Tsuchiya, Teruo |
| description | A direct-injection HPLC-based method has been developed for determining amounts of micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column. The method is easy to perform and requires only 10
μL of a filtered plasma sample. The chromatographic separations were carried out with a gradient mode. The fluorescence detection wavelengths of excitation and emission were set at 273
nm and 464
nm, respectively. Retention times for micafungin and IS were 22.4 and 23.7
min, respectively. Micafungin and FR195743 (IS) peaks were completely separated with little tailing, and no interference was observed. The calibration curve of micafungin showed good linearity in the range of 0.5–20.0
μg/mL (
r
2
=
1.00). The intra-day accuracy ranged from −4.5 to 5.3%. The inter-day accuracy ranged from −9.8 to 1.5%. The precisions were less than 10%. This method is useful for the determination of micafungin in human plasma. |
| doi_str_mv | 10.1016/j.jchromb.2011.03.008 |
| format | article |
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μL of a filtered plasma sample. The chromatographic separations were carried out with a gradient mode. The fluorescence detection wavelengths of excitation and emission were set at 273
nm and 464
nm, respectively. Retention times for micafungin and IS were 22.4 and 23.7
min, respectively. Micafungin and FR195743 (IS) peaks were completely separated with little tailing, and no interference was observed. The calibration curve of micafungin showed good linearity in the range of 0.5–20.0
μg/mL (
r
2
=
1.00). The intra-day accuracy ranged from −4.5 to 5.3%. The inter-day accuracy ranged from −9.8 to 1.5%. The precisions were less than 10%. This method is useful for the determination of micafungin in human plasma.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2011.03.008</identifier><identifier>PMID: 21439916</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Calibration ; Chromatography ; Chromatography, High Pressure Liquid - instrumentation ; Chromatography, High Pressure Liquid - methods ; Direct injection ; Dispersion hardening alloys ; Echinocandins - blood ; Emission ; Fluorescence ; Fluorescence detection ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; high performance liquid chromatography ; Human ; Humans ; hydrophilicity ; Hydrophobic and Hydrophilic Interactions ; hydrophobicity ; Interference ; Linear Models ; Lipopeptides - blood ; Liquid chromatography ; Medical sciences ; Micafungin ; Pharmacology. Drug treatments ; Reproducibility of Results ; Sensitivity and Specificity ; Wavelengths</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-04, Vol.879 (13), p.1029-1032</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-5796f4d5544f8f88097d3ddab60832d6dac84f4b5c844cb04e42198973d95bd13</citedby><cites>FETCH-LOGICAL-c517t-5796f4d5544f8f88097d3ddab60832d6dac84f4b5c844cb04e42198973d95bd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24045842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21439916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uranishi, Hiroaki</creatorcontrib><creatorcontrib>Nakamura, Mitsuhiro</creatorcontrib><creatorcontrib>Nakamura, Hiroki</creatorcontrib><creatorcontrib>Ikeda, Yukari</creatorcontrib><creatorcontrib>Otsuka, Mayuko</creatorcontrib><creatorcontrib>Kato, Zenichiro</creatorcontrib><creatorcontrib>Tsuchiya, Teruo</creatorcontrib><title>Direct-injection HPLC method of measuring micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>A direct-injection HPLC-based method has been developed for determining amounts of micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column. The method is easy to perform and requires only 10
μL of a filtered plasma sample. The chromatographic separations were carried out with a gradient mode. The fluorescence detection wavelengths of excitation and emission were set at 273
nm and 464
nm, respectively. Retention times for micafungin and IS were 22.4 and 23.7
min, respectively. Micafungin and FR195743 (IS) peaks were completely separated with little tailing, and no interference was observed. The calibration curve of micafungin showed good linearity in the range of 0.5–20.0
μg/mL (
r
2
=
1.00). The intra-day accuracy ranged from −4.5 to 5.3%. The inter-day accuracy ranged from −9.8 to 1.5%. The precisions were less than 10%. This method is useful for the determination of micafungin in human plasma.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Direct injection</subject><subject>Dispersion hardening alloys</subject><subject>Echinocandins - blood</subject><subject>Emission</subject><subject>Fluorescence</subject><subject>Fluorescence detection</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>high performance liquid chromatography</subject><subject>Human</subject><subject>Humans</subject><subject>hydrophilicity</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>hydrophobicity</subject><subject>Interference</subject><subject>Linear Models</subject><subject>Lipopeptides - blood</subject><subject>Liquid chromatography</subject><subject>Medical sciences</subject><subject>Micafungin</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Wavelengths</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkV-L1DAUxYso7h_9CGpeZH1p96ZJmvRJZFZdYWCFdcG3kCbpTIY2mU2mCwt-eFOn6ptC4BzC796b3FMUrzBUGHBzuat2ehvD2FU1YFwBqQDEk-IUC05KwpvvT7NnHEqoSX1SnKW0A8AcOHlenNSYkrbFzWnx48pFqw-l87ssLnh0_XW9QqM9bINBoc9OpSk6v0Gj06qf_MZ5lM92GpVH-0GlUaEpzYBCPjzYAW0fTQz7beicvly8G5zO9110Bt1c3SIdhmn0L4pnvRqSfbnoeXH36eO31XW5vvn8ZfVhXWqG-aFkvG16ahijtBe9ENByQ4xRXQOC1KYxSgva045loboDammNW9FyYlrWGUzOi4tj330M95NNBzm6pO0wKG_DlKRoMBO8Acjku3-SuOGYQt7x3JQdUR1DStH2ch_dqOKjxCDniOROLhHJOSIJROaIct3rZcTUjdb8qfqdSQbeLoBKWg19VF679JejQJmgdebeHLleBak2MTN3t3lS_gc0rG5n4v2RsHm5D85GmbSzXlvzK3RpgvvPY38CdrG7uw</recordid><startdate>20110415</startdate><enddate>20110415</enddate><creator>Uranishi, Hiroaki</creator><creator>Nakamura, Mitsuhiro</creator><creator>Nakamura, Hiroki</creator><creator>Ikeda, Yukari</creator><creator>Otsuka, Mayuko</creator><creator>Kato, Zenichiro</creator><creator>Tsuchiya, Teruo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>7X8</scope></search><sort><creationdate>20110415</creationdate><title>Direct-injection HPLC method of measuring micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column</title><author>Uranishi, Hiroaki ; Nakamura, Mitsuhiro ; Nakamura, Hiroki ; Ikeda, Yukari ; Otsuka, Mayuko ; Kato, Zenichiro ; Tsuchiya, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-5796f4d5544f8f88097d3ddab60832d6dac84f4b5c844cb04e42198973d95bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Direct injection</topic><topic>Dispersion hardening alloys</topic><topic>Echinocandins - blood</topic><topic>Emission</topic><topic>Fluorescence</topic><topic>Fluorescence detection</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>high performance liquid chromatography</topic><topic>Human</topic><topic>Humans</topic><topic>hydrophilicity</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>hydrophobicity</topic><topic>Interference</topic><topic>Linear Models</topic><topic>Lipopeptides - blood</topic><topic>Liquid chromatography</topic><topic>Medical sciences</topic><topic>Micafungin</topic><topic>Pharmacology. Drug treatments</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Wavelengths</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uranishi, Hiroaki</creatorcontrib><creatorcontrib>Nakamura, Mitsuhiro</creatorcontrib><creatorcontrib>Nakamura, Hiroki</creatorcontrib><creatorcontrib>Ikeda, Yukari</creatorcontrib><creatorcontrib>Otsuka, Mayuko</creatorcontrib><creatorcontrib>Kato, Zenichiro</creatorcontrib><creatorcontrib>Tsuchiya, Teruo</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uranishi, Hiroaki</au><au>Nakamura, Mitsuhiro</au><au>Nakamura, Hiroki</au><au>Ikeda, Yukari</au><au>Otsuka, Mayuko</au><au>Kato, Zenichiro</au><au>Tsuchiya, Teruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct-injection HPLC method of measuring micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2011-04-15</date><risdate>2011</risdate><volume>879</volume><issue>13</issue><spage>1029</spage><epage>1032</epage><pages>1029-1032</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A direct-injection HPLC-based method has been developed for determining amounts of micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column. The method is easy to perform and requires only 10
μL of a filtered plasma sample. The chromatographic separations were carried out with a gradient mode. The fluorescence detection wavelengths of excitation and emission were set at 273
nm and 464
nm, respectively. Retention times for micafungin and IS were 22.4 and 23.7
min, respectively. Micafungin and FR195743 (IS) peaks were completely separated with little tailing, and no interference was observed. The calibration curve of micafungin showed good linearity in the range of 0.5–20.0
μg/mL (
r
2
=
1.00). The intra-day accuracy ranged from −4.5 to 5.3%. The inter-day accuracy ranged from −9.8 to 1.5%. The precisions were less than 10%. This method is useful for the determination of micafungin in human plasma.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21439916</pmid><doi>10.1016/j.jchromb.2011.03.008</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-04, Vol.879 (13), p.1029-1032 |
| issn | 1570-0232 1873-376X |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Calibration Chromatography Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Direct injection Dispersion hardening alloys Echinocandins - blood Emission Fluorescence Fluorescence detection Fundamental and applied biological sciences. Psychology General pharmacology high performance liquid chromatography Human Humans hydrophilicity Hydrophobic and Hydrophilic Interactions hydrophobicity Interference Linear Models Lipopeptides - blood Liquid chromatography Medical sciences Micafungin Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Wavelengths |
| title | Direct-injection HPLC method of measuring micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column |
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