Metabonomic investigation of human Schistosoma mansoni infection

Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Inves...

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Bibliographic Details
Published in:Molecular bioSystems 2011-05, Vol.7 (5), p.1473-1480
Main Authors: Balog, Crina I A, Meissner, Axel, Göraler, Sibel, Bladergroen, Marco R, Vennervald, Birgitte J, Mayboroda, Oleg A, Deelder, André M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Animals
Anthelmintics - therapeutic use
Biomarkers - metabolism
Biomarkers - urine
Child
Cohort Studies
Feces - parasitology
Female
Host-Parasite Interactions
Humans
Magnetic Resonance Spectroscopy
Male
Metabolomics - methods
Middle Aged
Multivariate Analysis
Praziquantel - therapeutic use
Schistosoma mansoni
Schistosoma mansoni - drug effects
Schistosoma mansoni - isolation & purification
Schistosoma mansoni - physiology
Schistosomiasis mansoni - drug therapy
Schistosomiasis mansoni - metabolism
Schistosomiasis mansoni - parasitology
Time Factors
Uganda
Young Adult
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Summary:Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Investigation of the host-parasite interaction at the molecular level and identification of biomarkers of infection and infection-related morbidity would be of value for improved strategies for treatment and morbidity control. To this end, we conducted a nuclear magnetic resonance (NMR) based metabonomics study involving a well-characterized cohort of 447 individuals from a rural area in Uganda near Lake Victoria with a high prevalence of Schistosoma mansoni, a species predominantly occurring in Africa including Madagascar and parts of South America. Cohort samples were collected from individuals at five time-points, before and after (one or two times) chemotherapy with praziquantel (PZQ). Using supervised multivariate statistical analysis of the recorded one-dimensional (1D) NMR spectra, we were able to discriminate infected from uninfected individuals in two age groups (children and adults) based on differences in their urinary profiles. The potential molecular markers of S. mansoni infection were found to be primarily linked to changes in gut microflora, energy metabolism and liver function. These findings are in agreement with data from earlier studies on S. mansoni infection in experimental animals and thus provide corroborating evidence for the existence of metabolic response specific for this infection.
ISSN:1742-206X
1742-2051
DOI:10.1039/c0mb00262c