Perinatal exposure of rats to Bisphenol A affects fertility of male offspring—An overview

Endocrine disruptors (ED) induce both functional and behavioral reproductive abnormalities. Bisphenol A (BPA) is a known ED that leaches from polycarbonate plastics, as such human exposure is common. Maternal BPA exposure has been shown to have negative effects on the fertility of male offspring. Pr...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2011-04, Vol.31 (3), p.359-362
Main Authors: Salian, Smita, Doshi, Tanvi, Vanage, Geeta
Format: Article
Language:English
Subjects:
Animals
Benzhydryl Compounds
Biological and medical sciences
Bisphenol A
Diabetes Mellitus - chemically induced
Embryology: invertebrates and vertebrates. Teratology
Endocrine disrupters
Epigenesis, Genetic - drug effects
Estrogens, Non-Steroidal - toxicity
Female
Fertility
Fertility - drug effects
Fertility - physiology
Fundamental and applied biological sciences. Psychology
Genitalia, Male - drug effects
Genitalia, Male - pathology
Infertility, Male - chemically induced
Male
Maternal Exposure
Medical sciences
Obesity - chemically induced
Perinatal exposure
Phenols - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Rats
Spermatogenesis - drug effects
Spermatogenesis - physiology
Teratology. Teratogens
Toxicology
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Summary:Endocrine disruptors (ED) induce both functional and behavioral reproductive abnormalities. Bisphenol A (BPA) is a known ED that leaches from polycarbonate plastics, as such human exposure is common. Maternal BPA exposure has been shown to have negative effects on the fertility of male offspring. Pregnant rats exposed perinatally to environmentally relevant doses of BPA gave birth to offspring with significantly impaired spermatogenesis and fertility. Perinatal exposure had deleterious effects on the male germ line which manifested as impairments in the fertility of F 1 male offspring and subsequent F 2 and F 3 generations. This overview is an attempt to summarize the currently available data in the literature with regards to perinatal BPA exposure and male fertility.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2010.10.008