Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure

The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening low-frequency fluctuations in cerebral blood flow has not been clearly examined. In this study, we quantitatively assessed the contribution...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2011-04, Vol.110 (4), p.917-925
Main Authors: CHAN, Gregory S. H, AINSLIE, Philip N, WILLIE, Chris K, TAYLOR, Chloe E, ATKINSON, Greg, JONES, Helen, LOVELL, Nigel H, TZENG, Yu-Chieh
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Flow Velocity - physiology
Blood pressure
Blood Pressure - physiology
Cerebrovascular Circulation - physiology
Comparative analysis
Electrocardiography
Female
Fundamental and applied biological sciences. Psychology
Hemodynamics - physiology
Humans
Intervention
Male
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiology
Studies
Ultrasonography, Doppler, Transcranial
Veins & arteries
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Summary:The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening low-frequency fluctuations in cerebral blood flow has not been clearly examined. In this study, we quantitatively assessed the contribution of arterial Windkessel (peripheral compliance and resistance) in the dynamic cerebral blood flow response to relatively large and acute changes in blood pressure. Middle cerebral artery flow velocity (MCA(V); transcranial Doppler) and arterial blood pressure were recorded from 14 healthy subjects. Low-pass-filtered pressure-flow responses (
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.01407.2010