Aldosterone paradox: differential regulation of ion transport in distal nephron

The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2011-04, Vol.26 (2), p.115-123
Main Authors: Arroyo, Juan Pablo, Ronzaud, Caroline, Lagnaz, Dagmara, Staub, Olivier, Gamba, Gerardo
Format: Article
Language:English
Subjects:
Aldosterone - physiology
Animals
Humans
Ion Transport - physiology
Kidney Tubules, Distal - physiology
Potassium - metabolism
Sodium Chloride - metabolism
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Summary:The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00049.2010