Liver transplantation in a patient treated by sorafenib for hepatocellular carcinoma

Summary Sorafenib is a multikinase inhibitor currently used in the palliative treatment of advanced hepatocellular carcinoma. In patients with small hepatocellular carcinoma, sorafenib could be suggested as neoadjuvant therapy to control tumor growth during waiting time for liver transplantation. Ho...

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Bibliographic Details
Published in:Clinics and research in hepatology and gastroenterology 2011-03, Vol.35 (3), p.234-236
Main Authors: Borentain, P, Gregoire, E, Hardwigsen, J, Garcia, S, Durieux, O, Le Treut, Y.-P, Gérolami, R
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Benzenesulfonates - therapeutic use
Biological and medical sciences
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - surgery
Combined Modality Therapy
Fatal Outcome
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Internal Medicine
Liver Neoplasms - drug therapy
Liver Neoplasms - surgery
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Middle Aged
Niacinamide - analogs & derivatives
Phenylurea Compounds
Pyridines - therapeutic use
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tumors
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Summary:Summary Sorafenib is a multikinase inhibitor currently used in the palliative treatment of advanced hepatocellular carcinoma. In patients with small hepatocellular carcinoma, sorafenib could be suggested as neoadjuvant therapy to control tumor growth during waiting time for liver transplantation. However, up to now, safety of liver transplantation in patients undergoing sorafenib treatment is not known. Herein, we report a case of successful liver transplantation in a patient treated by sorafenib for hepatocellular carcinoma. In this patient, liver transplantation was performed safely and histological examination of explanted liver evidenced complete necrosis of the largest tumor nodule.
ISSN:2210-7401
2210-741X
DOI:10.1016/j.clinre.2010.12.007