Surgical Outcome in 90 Patients with Craniopharyngioma: An Evaluation of Transsphenoidal Surgery

• Published in: World neurosurgery 2010-08, Vol.74 (2), p.320-330
• Main Authors: Yamada, Shozo, Fukuhara, Noriaki, Oyama, Kenichi, Takeshita, Akira, Takeuchi, Yasuharu, Ito, Junko, Inoshita, Naoko
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Cerebrospinal fluid leakage; Child; Child, Preschool; Craniopharyngioma; Craniopharyngioma - cerebrospinal fluid; Craniopharyngioma - pathology; Craniopharyngioma - surgery; Extended endonasal approach; Female; Follow-Up Studies; Hormones - blood; Humans; Image Interpretation, Computer-Assisted; Long-term outcome; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local; Neurosurgery; Neurosurgical Procedures - methods; Pituitary Gland - pathology; Pituitary Neoplasms - cerebrospinal fluid; Pituitary Neoplasms - pathology; Pituitary Neoplasms - surgery; Postoperative Complications - mortality; Postoperative Complications - pathology; Sphenoid Bone - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tomography, X-Ray Computed; Transsphenoidal surgery; Treatment Outcome; Vision Disorders - etiology; Vision Tests; Vision, Ocular; Young Adult
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2010.06.014

Objective To analyze surgical outcomes in 90 patients with craniopharyngioma treated by standard transsphenoidal surgery (TSS) or extended transsphenoidal surgery (eTSS). Methods From 1990-2008, 90 patients (64 adults and 26 children) underwent TSS for craniopharyngioma (34 subdiaphragmatic and 56 supradiaphragmatic). TSS was performed as the initial surgery in 62 patients and as the second procedure in 28 patients. Results Total tumor removal was achieved in 70 (77.8%) patients, subtotal removal was achieved in 17 (18.9%), and partial removal was achieved in 3 (3.3%). Total removal was more often accomplished in initial surgery (56 of 62 [90.3%]) than second surgery (14 of 28 [50.0%]). Postoperative deterioration of anterior pituitary hormones developed in 31 of 47 (66.0%) patients with preoperative normal function or partial anterior pituitary loss. New-onset postoperative diabetes insipidus (DI) developed in 35 of 67 (52.2%) patients. Of 61 patients with preoperative visual loss, 55 (90.2%) noted some degree of visual improvement after surgery. The early postoperative mortality rate was 2.2% (2 of 90 patients). Cerebrospinal fluid (CSF) leakage occurred in 11 patients (12.2%), and 5 patients required surgical repair of the leak. Tumor recurrence was observed in seven (7.8%) patients during a mean follow-up period of 4.6 years. Conclusions Most craniopharyngiomas including the supradiaphragmatic type can be removed safely by TSS with a good outcome, although endocrine function frequently worsens after surgery. Dural fascia graft is a very effective technique to prevent CSF leaks, especially after eTSS.