Ovine abortion associated with toxoplasmosis: serological, anatomo-pathological and immunohistochemistry characterization

Ovine toxoplasmosis is a major cause of abortion and placentitis. Lambs with congenital infection are born with encephalitis. Abortions occurred between May and August 2006 in an estate in Três Palmeiras, southern Brazil. This study aimed to assess the frequency of abortion associated with toxoplasm...

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Bibliographic Details
Published in:Revista brasileira de parasitologia veterinaria 2008-09, Vol.17 Suppl 1, p.204-208
Main Authors: Da Motta, Adriana C, Vieira, Maria Isabel B, Bondan, Carlos, Edelweiss, Maria Isabel A, Dametto, Marlos Augusto, Gomes, Angela
Format: Article
Language:Portuguese
Subjects:
Abortion, Veterinary - blood
Abortion, Veterinary - parasitology
Abortion, Veterinary - pathology
Animals
Female
Immunohistochemistry
Pregnancy
Sheep
Toxoplasmosis, Animal - blood
Toxoplasmosis, Animal - complications
Toxoplasmosis, Animal - pathology
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Summary:Ovine toxoplasmosis is a major cause of abortion and placentitis. Lambs with congenital infection are born with encephalitis. Abortions occurred between May and August 2006 in an estate in Três Palmeiras, southern Brazil. This study aimed to assess the frequency of abortion associated with toxoplasmosis among ewes in southern Brazil using indirect hemagglutination and pathoanatomical and immunohistochemical analyses. Blood samples were collected from nine animals for indirect hemagglutination. One fetus underwent necropsy and histopathological and immunohistochemical analyses. Three samples, one of which belonged to the necropsied animals mother, were positive on the serological test. The necropsy revealed pale foci in the liver, lungs with a marbled appearance, heart with severe pallor and brain and cerebellar congestion. Fragments of all organs were collected, fixed in 10% buffered formalin, processed, and stained with hematoxylin-eosin. Microscopically, there were cysts and tachyzoites in the brain in areas of malacia with microgliosis and lymphoplasmacytic infiltration, suggesting toxoplasmic encephalitis. There was also interstitial pneumonia, centrolobular necrosis with structures compatible with tachyzoites, focal lymphocytic myocarditis and acute tubular nephrosis. The immunohistochemical test was positive for Toxoplasma gondii. The results allowed diagnosing the ovine toxoplasmosis.
ISSN:1984-2961