Effects of smoking during pregnancy on the optic nerve neurodevelopment

Abstract Background Tobacco smoking during pregnancy alters neurodevelopment. Optical coherence tomography (OCT) provides precise measurements of the retinal nerve fiber layer (RNFL), which forms part of the central nervous system. Aims To assess using the OCT how smoking during pregnancy would affe...

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Bibliographic Details
Published in:Early human development 2011-05, Vol.87 (5), p.331-334
Main Authors: Pueyo, Victoria, Güerri, Noemí, Oros, Daniel, Valle, Sofía, Tuquet, Helena, González, Inmaculada, Ferrer, Concepción, Pablo, Luis Emilio
Format: Article
Language:English
Subjects:
Adolescent
Advanced Basic Science
Age
Biological and medical sciences
Birth weight
Central nervous system
Child
Child, Preschool
Children
Cross-Sectional Studies
Development
Embryology: invertebrates and vertebrates. Teratology
Female
Fetal Development
Fibers
Fundamental and applied biological sciences. Psychology
Gestational age
Humans
Infant, Newborn
Infants
Male
Neonatal and Perinatal Medicine
Neurodevelopment
Optic nerve
Optic Nerve - anatomy & histology
Optic Nerve - embryology
Optic Nerve - growth & development
Optical coherence tomography
Pregnancy
Prenatal Exposure Delayed Effects
Progeny
Regression analysis
Retina
Retinal nerve fiber layer
Smoke
Smoking - adverse effects
Tobacco smoking
Tomography
Tomography, Optical Coherence - methods
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Summary:Abstract Background Tobacco smoking during pregnancy alters neurodevelopment. Optical coherence tomography (OCT) provides precise measurements of the retinal nerve fiber layer (RNFL), which forms part of the central nervous system. Aims To assess using the OCT how smoking during pregnancy would affect optic nerve development as detected in human offspring. Study design Visual examination and OCT were performed on a group of children (n = 70; 4.15-13.50 years of age), classified as being exposed or not to maternal smoking during gestational period. The association between smoking during pregnancy and RNFL thickness was assessed by a linear regression analysis adjusted for possible confounding factors. Results Although visual outcomes did not differ between groups, a significant decrease in the RNFL thickness was found in the group of infants exposed to smoke (105.3 vs 95.6; p = 0.002), even when adjusting for gestational age, birth weight or gender. Conclusions OCT measurements show that intrautero exposure to tobacco smoke interferes with the development of the optic nerve.
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2011.01.042