Interferon-lambda serum levels in hepatitis C

Background & Aims Dendritic cells (DCs) trigger adaptive immune responses and are an important source of antiviral cytokines. In hepatitis C virus (HCV) infection DC function is markedly impaired. Thus far, studies have focused on types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) a...

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Bibliographic Details
Published in:Journal of hepatology 2011-05, Vol.54 (5), p.859-865
Main Authors: Langhans, Bettina, Kupfer, Bernd, Braunschweiger, Ingrid, Arndt, Simone, Schulte, Wibke, Nischalke, Hans Dieter, Nattermann, Jacob, Oldenburg, Johannes, Sauerbruch, Tilman, Spengler, Ulrich
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD - immunology
Biological and medical sciences
Cross-Sectional Studies
Dendritic cells (DCs)
Dendritic Cells - immunology
Female
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Genotype
Hepacivirus - genetics
Hepacivirus - immunology
Hepatitis C virus (HCV)
Hepatitis C, Chronic - immunology
Hepatitis C, Chronic - metabolism
Hepatitis C, Chronic - virology
Human viral diseases
Humans
IFN-lambdas (IL-29, IL-28A/B)
IL-28B rs12979860 T/C polymorphism
Infectious diseases
Interferons
Interleukins - blood
Interleukins - genetics
Interleukins - immunology
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Prognosis
Tetraspanin 28
Toll-Like Receptor 2 - immunology
Viral diseases
Viral Envelope Proteins - genetics
Viral hepatitis
Viral Load - immunology
Viral Nonstructural Proteins - genetics
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Summary:Background & Aims Dendritic cells (DCs) trigger adaptive immune responses and are an important source of antiviral cytokines. In hepatitis C virus (HCV) infection DC function is markedly impaired. Thus far, studies have focused on types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) and IFN-lambda2/3 (IL-28A/B) serum levels in patients with different outcomes of HCV infection. Methods IFN-lambdas were measured by ELISAs detecting IL-29 or IL-28A and IL-28B, respectively. Results were stratified with respect to the recently discovered rs12979860 T/C polymorphism upstream of the IL-28B gene. Results In general IL-29 serum levels exceeded IL-28A/B at least twofold, with IL-29 and IL-28A/B levels being significantly higher in carriers of the rs12979860 C allele than in TT homozygous individuals ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2010.08.020