Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy

Background & Aims Vitamin D is an important immune modulator and preliminary data indicated an association between vitamin D deficiency and sustained virologic response (SVR) rates in hepatitis C virus (HCV) genotype 1 patients. We, therefore, performed a comprehensive analysis on the impact of...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepatology 2011-05, Vol.54 (5), p.887-893
Main Authors: Lange, Christian Markus, Bojunga, Jörg, Ramos-Lopez, Elizabeth, von Wagner, Michael, Hassler, Angela, Vermehren, Johannes, Herrmann, Eva, Badenhoop, Klaus, Zeuzem, Stefan, Sarrazin, Christoph
Format: Article
Language:English
Subjects:
1α-Hydroxylase polymorphism
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - immunology
Adult
Aged
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - therapeutic use
Antiviral therapy
Biological and medical sciences
Calcifediol - blood
Drug Resistance, Viral - immunology
Female
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Genotype
HCV genotype
Hepacivirus - drug effects
Hepacivirus - genetics
Hepacivirus - immunology
Hepatitis C virus
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - immunology
Human viral diseases
Humans
Infectious diseases
Interferon-alpha - therapeutic use
Male
Medical sciences
Middle Aged
Pegylated interferon-alfa
Pharmacology. Drug treatments
Polymorphism, Genetic - immunology
Promoter Regions, Genetic - genetics
Promoter Regions, Genetic - immunology
Receptors, Calcitriol - genetics
Retrospective Studies
Viral diseases
Viral hepatitis
Vitamin D deficiency
Vitamin D Deficiency - genetics
Vitamin D Deficiency - immunology
Vitamin D receptor polymorphism
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background & Aims Vitamin D is an important immune modulator and preliminary data indicated an association between vitamin D deficiency and sustained virologic response (SVR) rates in hepatitis C virus (HCV) genotype 1 patients. We, therefore, performed a comprehensive analysis on the impact of vitamin D serum levels and of genetic polymorphisms with functional relevance within the vitamin D cascade on chronic hepatitis C and its treatment. Methods Vitamin D serum levels, genetic polymorphisms within the vitamin D receptor and 1α-hydroxylase were determined in a cohort of 468 HCV genotype 1, 2, and 3 infected patients who were treated with interferon-alfa based regimens. Results Chronic hepatitis C was associated with a high incidence of severe vitamin D deficiency compared to controls (25(OH)D3
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2010.08.036