Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography

The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2011-05, Vol.107 (9), p.1270-1277
Main Authors: Ito, Tsuyoshi, MD, Terashima, Mitsuyasu, MD, Kaneda, Hideaki, MD, Nasu, Kenya, MD, Matsuo, Hitoshi, MD, Ehara, Mariko, MD, Kinoshita, Yoshihisa, MD, Kimura, Masashi, MD, Tanaka, Nobuyoshi, MD, Habara, Maoto, MD, Katoh, Osamu, MD, Suzuki, Takahiko, MD
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Comparative analysis
Confidence intervals
Correlation analysis
Female
Humans
Male
Medical sciences
Middle Aged
Plaque, Atherosclerotic - diagnosis
Plaque, Atherosclerotic - diagnostic imaging
Studies
Tomography
Tomography, Optical Coherence
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833
cites cdi_FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833
container_end_page 1277
container_issue 9
container_start_page 1270
container_title The American journal of cardiology
container_volume 107
creator Ito, Tsuyoshi, MD
Terashima, Mitsuyasu, MD
Kaneda, Hideaki, MD
Nasu, Kenya, MD
Matsuo, Hitoshi, MD
Ehara, Mariko, MD
Kinoshita, Yoshihisa, MD
Kimura, Masashi, MD
Tanaka, Nobuyoshi, MD
Habara, Maoto, MD
Katoh, Osamu, MD
Suzuki, Takahiko, MD
description The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence tomography. Based on optical coherence tomographic findings, lesions were classified as thin-capped fibroatheroma (TCFA; n = 37) and non-TCFA (n = 85). Mean computed tomographic density value of the lesion was lower and remodeling index was larger in the TCFA group (44.9 ± 19.2 vs 78.7 ± 25.0 HU, p
doi_str_mv 10.1016/j.amjcard.2010.12.036
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_862603429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002914911001263</els_id><sourcerecordid>2336823501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhJ4AsJMQpi7_ixBdQteKjUlGRWvZqOcmEekni4Ekq7Z0fjs0urdQLJ49Hz7yamXey7CWja0aZerdb22HX2NCuOU05vqZCPcpWrCp1zjQTj7MVpZTnmkl9kj1D3MUvY4V6mp1wJqSWFV1lvzd-mGxw6EfiO3I-kq279eQMERAHGOeU3S79CMHWPZBvvf21AKn3RMn8qncNkK9LPzv8GyaxZYaWXPvB_wh2utmTLQRckFxOs2tsH5EbCDBG-J55nj3pbI_w4vieZt8_fbzefMkvLj-fb84u8qaQfM5tBbStaMW15qourSxpzUGXBa21rK21paSVlJSqkmlpW9mBsBRkUQhVikqI0-ztQXcKPk6BsxkcNtD3dgS_oKkUV1RIriP5-gG580sYY3MRkkpqVqoIFQeoCR4xQGem4AYb9oZRk0wyO3M0ySSTDOMmmhTrXh3Fl3qA9q7qnysReHMELMaddcGOjcN7TjJRUZnm-XDgIC7t1kEw2Li029YFaGbTevffVt4_UGh6NyajfsIe8G5oZjAWmKt0UemgGIu3xJUQfwBlaMZ-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>864649176</pqid></control><display><type>article</type><title>Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography</title><source>Elsevier</source><creator>Ito, Tsuyoshi, MD ; Terashima, Mitsuyasu, MD ; Kaneda, Hideaki, MD ; Nasu, Kenya, MD ; Matsuo, Hitoshi, MD ; Ehara, Mariko, MD ; Kinoshita, Yoshihisa, MD ; Kimura, Masashi, MD ; Tanaka, Nobuyoshi, MD ; Habara, Maoto, MD ; Katoh, Osamu, MD ; Suzuki, Takahiko, MD</creator><creatorcontrib>Ito, Tsuyoshi, MD ; Terashima, Mitsuyasu, MD ; Kaneda, Hideaki, MD ; Nasu, Kenya, MD ; Matsuo, Hitoshi, MD ; Ehara, Mariko, MD ; Kinoshita, Yoshihisa, MD ; Kimura, Masashi, MD ; Tanaka, Nobuyoshi, MD ; Habara, Maoto, MD ; Katoh, Osamu, MD ; Suzuki, Takahiko, MD</creatorcontrib><description>The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence tomography. Based on optical coherence tomographic findings, lesions were classified as thin-capped fibroatheroma (TCFA; n = 37) and non-TCFA (n = 85). Mean computed tomographic density value of the lesion was lower and remodeling index was larger in the TCFA group (44.9 ± 19.2 vs 78.7 ± 25.0 HU, p &lt;0.0001; 1.14 ± 0.20 vs 0.95 ± 0.16, p &lt;0.0001, respectively). Mean computed tomographic density value was correlated and remodeling index was inversely correlated with fibrous cap thickness (r = 0.605, p &lt;0.0001; r = −0.591, p &lt;0.0001, respectively). Optimal threshold of mean computed tomographic value and remodeling index identified by receiver operating characteristic curve were 62.4 HU and 1.08 (area under the curve 0.859 and 0.781). Signet ringlike appearance was observed more frequently in the TCFA group (65% vs 16%, p &lt;0.0001). In multivariate analysis, independent predictors of TCFA were mean computed tomographic density value ≤62.4 HU (odds ratio 8.20, 95% confidential interval 2.49 to 27.0, p = 0.0005), remodeling index ≥1.08 (odds ratio 6.10, 95% confidential interval 2.04 to 18.2, p = 0.0012), and signet ringlike appearance (odds ratio 6.33, 95% confidential interval 2.03 to 19.7, p = 0.0014). In conclusion, based on comparisons with optical coherence tomographic findings, 64-slice MSCT may have the potential to detect vulnerable plaque.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2010.12.036</identifier><identifier>PMID: 21349480</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Comparative analysis ; Confidence intervals ; Correlation analysis ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Plaque, Atherosclerotic - diagnosis ; Plaque, Atherosclerotic - diagnostic imaging ; Studies ; Tomography ; Tomography, Optical Coherence ; Tomography, X-Ray Computed</subject><ispartof>The American journal of cardiology, 2011-05, Vol.107 (9), p.1270-1277</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. May 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833</citedby><cites>FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24138043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21349480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Tsuyoshi, MD</creatorcontrib><creatorcontrib>Terashima, Mitsuyasu, MD</creatorcontrib><creatorcontrib>Kaneda, Hideaki, MD</creatorcontrib><creatorcontrib>Nasu, Kenya, MD</creatorcontrib><creatorcontrib>Matsuo, Hitoshi, MD</creatorcontrib><creatorcontrib>Ehara, Mariko, MD</creatorcontrib><creatorcontrib>Kinoshita, Yoshihisa, MD</creatorcontrib><creatorcontrib>Kimura, Masashi, MD</creatorcontrib><creatorcontrib>Tanaka, Nobuyoshi, MD</creatorcontrib><creatorcontrib>Habara, Maoto, MD</creatorcontrib><creatorcontrib>Katoh, Osamu, MD</creatorcontrib><creatorcontrib>Suzuki, Takahiko, MD</creatorcontrib><title>Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence tomography. Based on optical coherence tomographic findings, lesions were classified as thin-capped fibroatheroma (TCFA; n = 37) and non-TCFA (n = 85). Mean computed tomographic density value of the lesion was lower and remodeling index was larger in the TCFA group (44.9 ± 19.2 vs 78.7 ± 25.0 HU, p &lt;0.0001; 1.14 ± 0.20 vs 0.95 ± 0.16, p &lt;0.0001, respectively). Mean computed tomographic density value was correlated and remodeling index was inversely correlated with fibrous cap thickness (r = 0.605, p &lt;0.0001; r = −0.591, p &lt;0.0001, respectively). Optimal threshold of mean computed tomographic value and remodeling index identified by receiver operating characteristic curve were 62.4 HU and 1.08 (area under the curve 0.859 and 0.781). Signet ringlike appearance was observed more frequently in the TCFA group (65% vs 16%, p &lt;0.0001). In multivariate analysis, independent predictors of TCFA were mean computed tomographic density value ≤62.4 HU (odds ratio 8.20, 95% confidential interval 2.49 to 27.0, p = 0.0005), remodeling index ≥1.08 (odds ratio 6.10, 95% confidential interval 2.04 to 18.2, p = 0.0012), and signet ringlike appearance (odds ratio 6.33, 95% confidential interval 2.03 to 19.7, p = 0.0014). In conclusion, based on comparisons with optical coherence tomographic findings, 64-slice MSCT may have the potential to detect vulnerable plaque.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Comparative analysis</subject><subject>Confidence intervals</subject><subject>Correlation analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plaque, Atherosclerotic - diagnosis</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Studies</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><subject>Tomography, X-Ray Computed</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkk1v1DAQhiMEokvhJ4AsJMQpi7_ixBdQteKjUlGRWvZqOcmEekni4Ekq7Z0fjs0urdQLJ49Hz7yamXey7CWja0aZerdb22HX2NCuOU05vqZCPcpWrCp1zjQTj7MVpZTnmkl9kj1D3MUvY4V6mp1wJqSWFV1lvzd-mGxw6EfiO3I-kq279eQMERAHGOeU3S79CMHWPZBvvf21AKn3RMn8qncNkK9LPzv8GyaxZYaWXPvB_wh2utmTLQRckFxOs2tsH5EbCDBG-J55nj3pbI_w4vieZt8_fbzefMkvLj-fb84u8qaQfM5tBbStaMW15qourSxpzUGXBa21rK21paSVlJSqkmlpW9mBsBRkUQhVikqI0-ztQXcKPk6BsxkcNtD3dgS_oKkUV1RIriP5-gG580sYY3MRkkpqVqoIFQeoCR4xQGem4AYb9oZRk0wyO3M0ySSTDOMmmhTrXh3Fl3qA9q7qnysReHMELMaddcGOjcN7TjJRUZnm-XDgIC7t1kEw2Li029YFaGbTevffVt4_UGh6NyajfsIe8G5oZjAWmKt0UemgGIu3xJUQfwBlaMZ-</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Ito, Tsuyoshi, MD</creator><creator>Terashima, Mitsuyasu, MD</creator><creator>Kaneda, Hideaki, MD</creator><creator>Nasu, Kenya, MD</creator><creator>Matsuo, Hitoshi, MD</creator><creator>Ehara, Mariko, MD</creator><creator>Kinoshita, Yoshihisa, MD</creator><creator>Kimura, Masashi, MD</creator><creator>Tanaka, Nobuyoshi, MD</creator><creator>Habara, Maoto, MD</creator><creator>Katoh, Osamu, MD</creator><creator>Suzuki, Takahiko, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography</title><author>Ito, Tsuyoshi, MD ; Terashima, Mitsuyasu, MD ; Kaneda, Hideaki, MD ; Nasu, Kenya, MD ; Matsuo, Hitoshi, MD ; Ehara, Mariko, MD ; Kinoshita, Yoshihisa, MD ; Kimura, Masashi, MD ; Tanaka, Nobuyoshi, MD ; Habara, Maoto, MD ; Katoh, Osamu, MD ; Suzuki, Takahiko, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Comparative analysis</topic><topic>Confidence intervals</topic><topic>Correlation analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Plaque, Atherosclerotic - diagnosis</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Studies</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Tsuyoshi, MD</creatorcontrib><creatorcontrib>Terashima, Mitsuyasu, MD</creatorcontrib><creatorcontrib>Kaneda, Hideaki, MD</creatorcontrib><creatorcontrib>Nasu, Kenya, MD</creatorcontrib><creatorcontrib>Matsuo, Hitoshi, MD</creatorcontrib><creatorcontrib>Ehara, Mariko, MD</creatorcontrib><creatorcontrib>Kinoshita, Yoshihisa, MD</creatorcontrib><creatorcontrib>Kimura, Masashi, MD</creatorcontrib><creatorcontrib>Tanaka, Nobuyoshi, MD</creatorcontrib><creatorcontrib>Habara, Maoto, MD</creatorcontrib><creatorcontrib>Katoh, Osamu, MD</creatorcontrib><creatorcontrib>Suzuki, Takahiko, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Tsuyoshi, MD</au><au>Terashima, Mitsuyasu, MD</au><au>Kaneda, Hideaki, MD</au><au>Nasu, Kenya, MD</au><au>Matsuo, Hitoshi, MD</au><au>Ehara, Mariko, MD</au><au>Kinoshita, Yoshihisa, MD</au><au>Kimura, Masashi, MD</au><au>Tanaka, Nobuyoshi, MD</au><au>Habara, Maoto, MD</au><au>Katoh, Osamu, MD</au><au>Suzuki, Takahiko, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>107</volume><issue>9</issue><spage>1270</spage><epage>1277</epage><pages>1270-1277</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence tomography. Based on optical coherence tomographic findings, lesions were classified as thin-capped fibroatheroma (TCFA; n = 37) and non-TCFA (n = 85). Mean computed tomographic density value of the lesion was lower and remodeling index was larger in the TCFA group (44.9 ± 19.2 vs 78.7 ± 25.0 HU, p &lt;0.0001; 1.14 ± 0.20 vs 0.95 ± 0.16, p &lt;0.0001, respectively). Mean computed tomographic density value was correlated and remodeling index was inversely correlated with fibrous cap thickness (r = 0.605, p &lt;0.0001; r = −0.591, p &lt;0.0001, respectively). Optimal threshold of mean computed tomographic value and remodeling index identified by receiver operating characteristic curve were 62.4 HU and 1.08 (area under the curve 0.859 and 0.781). Signet ringlike appearance was observed more frequently in the TCFA group (65% vs 16%, p &lt;0.0001). In multivariate analysis, independent predictors of TCFA were mean computed tomographic density value ≤62.4 HU (odds ratio 8.20, 95% confidential interval 2.49 to 27.0, p = 0.0005), remodeling index ≥1.08 (odds ratio 6.10, 95% confidential interval 2.04 to 18.2, p = 0.0012), and signet ringlike appearance (odds ratio 6.33, 95% confidential interval 2.03 to 19.7, p = 0.0014). In conclusion, based on comparisons with optical coherence tomographic findings, 64-slice MSCT may have the potential to detect vulnerable plaque.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21349480</pmid><doi>10.1016/j.amjcard.2010.12.036</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2011-05, Vol.107 (9), p.1270-1277
issn 0002-9149
1879-1913
language eng
recordid cdi_proquest_miscellaneous_862603429
source Elsevier
subjects Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Comparative analysis
Confidence intervals
Correlation analysis
Female
Humans
Male
Medical sciences
Middle Aged
Plaque, Atherosclerotic - diagnosis
Plaque, Atherosclerotic - diagnostic imaging
Studies
Tomography
Tomography, Optical Coherence
Tomography, X-Ray Computed
title Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T12%3A01%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20In%20Vivo%20Assessment%20of%20Vulnerable%20Plaque%20by%2064-Slice%20Multislice%20Computed%20Tomography%20Versus%20Optical%20Coherence%20Tomography&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Ito,%20Tsuyoshi,%20MD&rft.date=2011-05-01&rft.volume=107&rft.issue=9&rft.spage=1270&rft.epage=1277&rft.pages=1270-1277&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/j.amjcard.2010.12.036&rft_dat=%3Cproquest_cross%3E2336823501%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c542t-a8e0d80829926b7a470b2e9750b94baaa7408440067194ad4fe3a0e4553673833%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=864649176&rft_id=info:pmid/21349480&rfr_iscdi=true