Adjuvant-induced arthritis induces c-Fos chronically in neurons in the hippocampus

Abstract Chronic pain, sickness behaviors, and cognitive decline are symptoms in rheumatoid arthritis. In the adjuvant-induced arthritis Lewis rat model, we examined the dynamics of c-Fos expression in the hippocampus, a brain region important for these symptoms. Brain sections were stained for c-Fo...

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Bibliographic Details
Published in:Journal of neuroimmunology 2011-01, Vol.230 (1), p.85-94
Main Authors: Carter, Jeffrey L, Lubahn, Cheri, Lorton, Dianne, Osredkar, Tracy, Der, T.C, Schaller, Jill, Evelsizer, Stephen, Flowers, Schari, Ruff, Natalie, Reese, Bethany, Bellinger, Denise L
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Arthritis, Experimental - metabolism
Arthritis, Experimental - pathology
Arthritis, Experimental - physiopathology
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - physiopathology
c-Fos
Gene Expression
Hippocampus
Hippocampus - metabolism
Hippocampus - pathology
Hippocampus - physiopathology
Immunohistochemistry
Male
Mycobacterium
Neural-immune
Neurology
Neurons - metabolism
Neurons - pathology
Proto-Oncogene Proteins c-fos - biosynthesis
Rats
Rats, Inbred Lew
Rheumatoid arthritis
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Summary:Abstract Chronic pain, sickness behaviors, and cognitive decline are symptoms in rheumatoid arthritis. In the adjuvant-induced arthritis Lewis rat model, we examined the dynamics of c-Fos expression in the hippocampus, a brain region important for these symptoms. Brain sections were stained for c-Fos using immunohistochemistry. c-Fos-positive nuclei were counted in CA1, CA2, CA3 and the dentate gyrus of the dorsal hippocampi from rats receiving no treatment or base-of-the-tail injections of (1 or 2) incomplete or complete Freund's adjuvant (low- or high-dose), (3), Mycobacterium butyricum cell wall suspended in saline, or (4) saline, and sacrificed 4, 14, 21, or 126 days post-immunization. Disease severity was evaluated by dorsoplantar foot pad widths and X-ray analysis. We report sustained dose- and subfield-dependent c-Fos expression with arthritis, but transient expression in nonarthritic groups, suggesting long-term genomic changes in rheumatoid arthritis that may be causal for behavioral changes, adaptation to chronic pain and/or cognitive decline associated with disease.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2010.09.005