Identification and characterization of immune complexes in the cerebrospinal fluid of patients with spinal cord schistosomiasis

Abstract The pathogenesis of neuroschistosomiasis is largely unknown. Available evidence suggests that it depends on the presence of parasite eggs in the nervous tissue and on the host's immune response. We investigated the presence of immune complexes (ICs) in the cerebrospinal fluid (CSF) of...

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Bibliographic Details
Published in:Journal of neuroimmunology 2011-01, Vol.230 (1), p.188-190
Main Authors: Ferrari, Teresa C.A, Faria, Luciana C, Vilaça, Tatiane S, Correa, Cristiane R, Góes, Alfredo M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigen-Antibody Complex - cerebrospinal fluid
Antigen-Antibody Complex - immunology
Antigens, Helminth - cerebrospinal fluid
Antigens, Helminth - immunology
Blotting, Western
Cerebrospinal fluid
Electrophoresis, Polyacrylamide Gel
Humans
Immune complexes
Neurology
Neuroschistosomiasis
Neuroschistosomiasis - cerebrospinal fluid
Neuroschistosomiasis - immunology
Schistosoma mansoni
Schistosomiasis mansoni - cerebrospinal fluid
Schistosomiasis mansoni - immunology
Spinal Cord Diseases - cerebrospinal fluid
Spinal Cord Diseases - immunology
Spinal cord schistosomiasis
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Summary:Abstract The pathogenesis of neuroschistosomiasis is largely unknown. Available evidence suggests that it depends on the presence of parasite eggs in the nervous tissue and on the host's immune response. We investigated the presence of immune complexes (ICs) in the cerebrospinal fluid (CSF) of four patients with spinal cord schistosomiasis (SCS), and performed their characterization. ICs containing soluble egg antigen of Schistosoma mansoni (SEA) were found in the CSF of all the SCS patients. To our knowledge, this is the first evidence of ICs containing schistosomal antigens in the CSF of patients with SCS. Further studies are necessary to confirm our findings and investigate the possible roles of ICs in the pathogenesis of this disease.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2010.08.016