Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy

Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191. Summary Background Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical co...

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Bibliographic Details
Published in:Clinical and experimental allergy 2011-02, Vol.41 (2), p.186-191
Main Authors: Miyahara, H., Okazaki, N., Nagakura, T., Korematsu, S., Izumi, T.
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Allergic diseases
Atopic dermatitis
Biological and medical sciences
Biomarkers - blood
Case-Control Studies
CCL17
CCL17 protein
Chemokine CCL17 - blood
chemokine TARC
Child, Preschool
Confidence intervals
CXCL10 protein
Dermatitis, Atopic - blood
Dermatitis, Atopic - congenital
Female
Fetal Blood - chemistry
Fundamental and applied biological sciences. Psychology
Fundamental immunology
gamma -Interferon
Heredity
Histocompatibility antigen HLA
Humans
Hypersensitivity
Immunoglobulin E
Immunopathology
Infant
Infant, Newborn
IP-10 protein
Leukocytes (eosinophilic)
Male
Medical sciences
Neonates
Pathogenesis
Predictive Value of Tests
Pregnancy
Prognosis
Reproducibility of Results
Serum levels
Skin allergic diseases. Stinging insect allergies
Stem cells
TARC
Umbilical cord
umbilical cord blood
Vagina
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Summary:Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191. Summary Background Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined. Objective Seventy paired full‐term and normal vaginal delivery newborns and their mothers were enrolled in this study. Methods To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN‐γ‐inducible protein 10 kDa (IP‐10; CXCL10), soluble HLA‐G (sHLA‐G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples. Results Serum CCL17 (rs=0.340, P
ISSN:0954-7894
1365-2222
DOI:10.1111/j.1365-2222.2010.03634.x