Arsonic acid-presenting superparamagnetic iron oxide for pH-responsive aggregation under slightly acidic conditions

We report the synthesis and characterization of the arsonic acid-presenting superparamagnetic iron oxide (SPIO). We used arsonoacetic acid as the ligand for SPIOs in aqueous media. The surface modification of the SPIOs was accomplished via the ligand exchange from undecanoic acid to the carboxyl moi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2011-04, Vol.19 (7), p.2282-2286
Main Authors: Minehara, Hiroki, Naka, Kensuke, Tanaka, Kazuo, Narita, Asako, Chujo, Yoshiki
Format: Article
Language:English
Subjects:
acidity
acids
Arsenicals - chemistry
Arsonic acid
Biological and medical sciences
Contrast media. Radiopharmaceuticals
Hydrogen-Ion Concentration
iron oxides
Magnetite Nanoparticles - chemistry
Medical sciences
Nanoparticle
pH-responsiveness
Pharmacology. Drug treatments
Superparamagnetic iron oxide
synthesis
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Summary:We report the synthesis and characterization of the arsonic acid-presenting superparamagnetic iron oxide (SPIO). We used arsonoacetic acid as the ligand for SPIOs in aqueous media. The surface modification of the SPIOs was accomplished via the ligand exchange from undecanoic acid to the carboxyl moiety of arsonoacetic acid. Consequently, the well-dispersed arsonic acid-presenting SPIOs in water were obtained. We found that the dispersion state of the arsonic acid-presenting SPIOs can be sharply regulated by pH changes in the biological significant region. The well dispersion state of the arsonic acid-presenting SPIOs can be maintained at the neutral pH region. In contrast, the arsonic acid-presenting SPIOs can sensitively form the aggregation below pH 6.1. Moreover, these dispersion states can be controlled reversibly by the pH alteration in the narrow region.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2011.02.027