The role of adenosine monophosphate kinase in remodeling white adipose tissue metabolism

Recent evidence indicates that the enzyme adenosine monophosphate (AMP) kinase exerts important fat-reducing effects in the adipose tissue, which has created great interest in this enzyme as a potential target for obesity treatment. This review summarizes our findings that chronic AMP kinase activat...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2011-04, Vol.39 (2), p.102-108
Main Authors: Gaidhu, Mandeep Pinky, Ceddia, Rolando Bacis
Format: Article
Language:English
Subjects:
Adenosine Kinase - metabolism
Adenosine Monophosphate - metabolism
Adipose Tissue, White - metabolism
Animals
Energy Metabolism - physiology
Enzyme Activation
Glucose - metabolism
Lipid Metabolism - physiology
Obesity - metabolism
Phosphotransferases - metabolism
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Summary:Recent evidence indicates that the enzyme adenosine monophosphate (AMP) kinase exerts important fat-reducing effects in the adipose tissue, which has created great interest in this enzyme as a potential target for obesity treatment. This review summarizes our findings that chronic AMP kinase activation remodels adipocyte glucose and lipid metabolism and enhances the ability of adipose tissue to dissipate energy within itself and reduce adiposity.
ISSN:0091-6331
1538-3008
DOI:10.1097/JES.0b013e31820ac03e