Multicystic mesothelioma of the pericardium

Multicystic mesothelioma is a well recognized but rare serosal tumor which mainly arises from the peritoneum in women and is considered as a benign lesion. This is the second case report of pericardial multicystic mesothelioma, which took a fatal clinical course. A 63‐year‐old man presented with pit...

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Bibliographic Details
Published in:Pathology international 2011-05, Vol.61 (5), p.319-321
Main Authors: Morita, Shigeki, Goto, Akiteru, Sakatani, Takashi, Ota, Satoshi, Murakawa, Tomohiro, Nakajima, Jun, Maeda, Eriko, Fukayama, Masashi
Format: Article
Language:English
Subjects:
Antimetabolites, Antineoplastic - therapeutic use
autopsy
Deoxycytidine - analogs & derivatives
Deoxycytidine - therapeutic use
Diagnosis, Differential
Fatal Outcome
Humans
Immunohistochemistry
Liver - pathology
Lung - pathology
Male
Mediastinum - pathology
mesothelioma
Mesothelioma, Cystic - diagnostic imaging
Mesothelioma, Cystic - drug therapy
Mesothelioma, Cystic - pathology
Middle Aged
multicystic mesothelioma
pericardium
Pericardium - diagnostic imaging
Pericardium - pathology
Peritoneal Neoplasms - diagnostic imaging
Peritoneal Neoplasms - drug therapy
Peritoneal Neoplasms - pathology
Pleural Cavity - pathology
postmortem CT
Tomography, X-Ray Computed
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Summary:Multicystic mesothelioma is a well recognized but rare serosal tumor which mainly arises from the peritoneum in women and is considered as a benign lesion. This is the second case report of pericardial multicystic mesothelioma, which took a fatal clinical course. A 63‐year‐old man presented with pitting edema, shortness of breath, and hoarseness. Radiological investigations revealed solid and cystic tumor of the pericardium which was continuously extending into the mediastinum and the liver. Pericardial biopsy showed micro‐cystic tumor lined by single layer of mesothelial cells without atypia, and the diagnosis was multicystic mesothelioma. Curative surgery could not be performed, and three years and four months later, the patient died because of the direct compression of the heart by the tumor. At autopsy, the tumor was found to be directly extending into the right pleural cavity and the right lung, besides the mediastinum and the liver. Neither malignant transformation nor metastatic tumor was identified.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2011.02654.x