Creatine as an antioxidant

Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP...

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Bibliographic Details
Published in:Amino acids 2011-05, Vol.40 (5), p.1385-1396
Main Authors: Sestili, Piero, Martinelli, C., Colombo, E., Barbieri, E., Potenza, L., Sartini, S., Fimognari, C.
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Animals
Antioxidants
Antioxidants - administration & dosage
Antioxidants - metabolism
Antioxidants - pharmacology
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Chromium
Creatine
Creatine - administration & dosage
Creatine - metabolism
Creatine - pharmacology
Dietary Supplements
Diffusion
Human
Humans
Life Sciences
Neurobiology
Proteomics
Reactive Oxygen Species - metabolism
Receiving
Review Article
Sole
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Summary:Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-011-0875-5