Vicarious Nucleophilic Substitution of α-Hydrogen of BODIPY and Its Extension to Direct Ethenylation

Direct, oxidizer-free substitution of the 3-hydrogen of BODIPY derivatives has been established through a vicarious nucleophilic substitution procedure. This methodology has been combined with a reversible Michael addition on nitrostyrenes to provide a novel, highly efficient entry to the valuable 3...

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Bibliographic Details
Published in:Organic letters 2011-03, Vol.13 (6), p.1470-1473
Main Authors: Leen, Volker, Van der Auweraer, Mark, Boens, Noël, Dehaen, Wim
Format: Article
Language:English
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Summary:Direct, oxidizer-free substitution of the 3-hydrogen of BODIPY derivatives has been established through a vicarious nucleophilic substitution procedure. This methodology has been combined with a reversible Michael addition on nitrostyrenes to provide a novel, highly efficient entry to the valuable 3-styrylated BODIPY dyes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200148u