Disease Correction the iPSC Way: Advances in iPSC-Based Therapy

Pluripotent stem cells possess the capacity for self‐renewal and the ability to differentiate into all cell types of the three embryonic germ layers. Accordingly, given their potential use in regenerative medicine, they have long attracted the attention of researchers. Embryonic stem cells (ESCs) re...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2011-05, Vol.89 (5), p.746-749
Main Authors: Sancho‐Martinez, I, Li, M, Izpisua Belmonte, JC
Format: Article
Language:English
Subjects:
Animals
Gene Targeting - trends
Genetic Therapy - trends
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - transplantation
Regenerative Medicine - trends
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Summary:Pluripotent stem cells possess the capacity for self‐renewal and the ability to differentiate into all cell types of the three embryonic germ layers. Accordingly, given their potential use in regenerative medicine, they have long attracted the attention of researchers. Embryonic stem cells (ESCs) represent the model pluripotent stem cell population. However, the use of ESCs in regenerative therapies faces major hurdles—namely, immune rejection and the necessity to use early‐stage embryos for ESC isolation. Clinical Pharmacology & Therapeutics (2011) 89 5, 746–749. doi:10.1038/clpt.2010.341
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2010.341