The Use of Induced Pluripotent Stem Cells in Drug Development

Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof‐of‐concept studies in drug development. This review focuses on the recen...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2011-05, Vol.89 (5), p.655-661
Main Authors: Inoue, H, Yamanaka, S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Differentiation - physiology
Cellular Reprogramming - physiology
Drug Discovery - methods
Drug Discovery - trends
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - trends
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - transplantation
Medical sciences
Pharmacology. Drug treatments
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Summary:Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof‐of‐concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine. Clinical Pharmacology & Therapeutics (2011) 89 5, 655–661. doi:10.1038/clpt.2011.38
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2011.38