Lipid mobilization and inflammatory responses during the transition period of dairy cows

Abstract The transition period of dairy cattle is characterized by dramatic changes in metabolism and host defense mechanisms that are associated with increased disease. Intense lipid mobilization from tissue stores is an important metabolic adaptation during the transition period that results in si...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2011-05, Vol.34 (3), p.281-289
Main Authors: Contreras, G. Andres, Sordillo, Lorraine M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Biological and medical sciences
Cattle
Dairy cows
Dairying
Endothelial Cells - immunology
Fatty Acids, Nonesterified - blood
Fatty Acids, Nonesterified - metabolism
Female
Fundamental and applied biological sciences. Psychology
Infectious Disease
Inflammation - immunology
Leukocytes - immunology
Lipid mobilization
Lipid Mobilization - physiology
Microbiology
Transition period
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Summary:Abstract The transition period of dairy cattle is characterized by dramatic changes in metabolism and host defense mechanisms that are associated with increased disease. Intense lipid mobilization from tissue stores is an important metabolic adaptation during the transition period that results in significant release of non-esterified fatty acids (NEFA) into the blood stream. Whereas these fatty acids are important sources of energy during times of increased metabolic demands, elevated concentrations of NEFA are known to disrupt several immune and inflammatory functions. This review will discuss the implications of lipid mobilization on inflammatory responses with special emphasis on leukocytes and endothelial cell functions during the transition period of dairy cows.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2011.01.004