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The surgeon and the patient with β-thalassaemia intermedia
Background: Unlike patients with β‐thalassaemia major, where lifelong transfusion and iron chelation therapy are necessary for survival, patients with β‐thalassaemia intermedia (TI) generally have a milder course and anaemia. The underlying pathophysiology of the disease still allows several complic...
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| Published in: | British journal of surgery 2011-06, Vol.98 (6), p.751-760 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 760 |
| container_issue | 6 |
| container_start_page | 751 |
| container_title | British journal of surgery |
| container_volume | 98 |
| creator | Saad, G. S. Abi Musallam, K. M. Taher, A. T. |
| description | Background:
Unlike patients with β‐thalassaemia major, where lifelong transfusion and iron chelation therapy are necessary for survival, patients with β‐thalassaemia intermedia (TI) generally have a milder course and anaemia. The underlying pathophysiology of the disease still allows several complications to manifest. Surgical management during the course of the disease is common but relevant data from the literature have never been reviewed constructively. This aim of this review was to highlight this clinical entity to the surgeon, and ensure optimal and timely intervention.
Methods:
The review was based on potentially relevant studies identified from an electronic search of MEDLINE and PubMed databases. There were no language or publication year restrictions. References in published articles were also reviewed.
Results:
Surgical intervention is often essential to ensure optimal control of the associated morbidity in TI. Several general considerations are necessary before surgical intervention with regard to anaemia, cardiovascular disease, thromboembolic events and the effects of iron overload. Splenectomy, cholecystectomy, leg ulcers, fractures and extramedullary pseudotumours are the most commonly encountered surgical problems related to TI.
Conclusion:
Awareness of TI and its associated morbidity is important so that appropriate preoperative care can occur. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
All surgeons should know about this |
| doi_str_mv | 10.1002/bjs.7533 |
| format | article |
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Unlike patients with β‐thalassaemia major, where lifelong transfusion and iron chelation therapy are necessary for survival, patients with β‐thalassaemia intermedia (TI) generally have a milder course and anaemia. The underlying pathophysiology of the disease still allows several complications to manifest. Surgical management during the course of the disease is common but relevant data from the literature have never been reviewed constructively. This aim of this review was to highlight this clinical entity to the surgeon, and ensure optimal and timely intervention.
Methods:
The review was based on potentially relevant studies identified from an electronic search of MEDLINE and PubMed databases. There were no language or publication year restrictions. References in published articles were also reviewed.
Results:
Surgical intervention is often essential to ensure optimal control of the associated morbidity in TI. Several general considerations are necessary before surgical intervention with regard to anaemia, cardiovascular disease, thromboembolic events and the effects of iron overload. Splenectomy, cholecystectomy, leg ulcers, fractures and extramedullary pseudotumours are the most commonly encountered surgical problems related to TI.
Conclusion:
Awareness of TI and its associated morbidity is important so that appropriate preoperative care can occur. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
All surgeons should know about this</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.7533</identifier><identifier>PMID: 21480198</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Anemia - prevention & control ; beta-Thalassemia - complications ; beta-Thalassemia - surgery ; Blood Transfusion - methods ; Chelation Therapy - methods ; Cholecystectomy - methods ; Facial Bones - surgery ; Gallstones - surgery ; Humans ; Intraoperative Care - methods ; Intraoperative Complications - prevention & control ; Iron Overload - prevention & control ; Leg Ulcer - surgery ; Osteoporotic Fractures - surgery ; Postoperative Complications - prevention & control ; Splenectomy - adverse effects</subject><ispartof>British journal of surgery, 2011-06, Vol.98 (6), p.751-760</ispartof><rights>Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3253-36496c8783165f20812cd12d0704aa0248dfcd3a895f67bb60678f2f94c005df3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21480198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saad, G. S. Abi</creatorcontrib><creatorcontrib>Musallam, K. M.</creatorcontrib><creatorcontrib>Taher, A. T.</creatorcontrib><title>The surgeon and the patient with β-thalassaemia intermedia</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
Unlike patients with β‐thalassaemia major, where lifelong transfusion and iron chelation therapy are necessary for survival, patients with β‐thalassaemia intermedia (TI) generally have a milder course and anaemia. The underlying pathophysiology of the disease still allows several complications to manifest. Surgical management during the course of the disease is common but relevant data from the literature have never been reviewed constructively. This aim of this review was to highlight this clinical entity to the surgeon, and ensure optimal and timely intervention.
Methods:
The review was based on potentially relevant studies identified from an electronic search of MEDLINE and PubMed databases. There were no language or publication year restrictions. References in published articles were also reviewed.
Results:
Surgical intervention is often essential to ensure optimal control of the associated morbidity in TI. Several general considerations are necessary before surgical intervention with regard to anaemia, cardiovascular disease, thromboembolic events and the effects of iron overload. Splenectomy, cholecystectomy, leg ulcers, fractures and extramedullary pseudotumours are the most commonly encountered surgical problems related to TI.
Conclusion:
Awareness of TI and its associated morbidity is important so that appropriate preoperative care can occur. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
All surgeons should know about this</description><subject>Anemia - prevention & control</subject><subject>beta-Thalassemia - complications</subject><subject>beta-Thalassemia - surgery</subject><subject>Blood Transfusion - methods</subject><subject>Chelation Therapy - methods</subject><subject>Cholecystectomy - methods</subject><subject>Facial Bones - surgery</subject><subject>Gallstones - surgery</subject><subject>Humans</subject><subject>Intraoperative Care - methods</subject><subject>Intraoperative Complications - prevention & control</subject><subject>Iron Overload - prevention & control</subject><subject>Leg Ulcer - surgery</subject><subject>Osteoporotic Fractures - surgery</subject><subject>Postoperative Complications - prevention & control</subject><subject>Splenectomy - adverse effects</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpFkE1OwzAQRi0EoqUgcQKUHauUsR3_RKxoBQVUChJFLC0ncahLkpbYUem1OAhnIlULrD6N5unTzEPoFEMfA5CLZO76glG6h7qYchYSzOU-6gKACDEltIOOnJsDYAqMHKIOwZEEHMsuupzOTOCa-s0sqkBXWeDbeam9NZUPVtbPgu-v0M90oZ3TprQ6sJU3dWkyq4_RQa4LZ0522UMvN9fT4W04fhzdDa_GYUoJoyHlUcxTKSTFnOUEJCZphkkGAiKtgUQyy9OMahmznIsk4cCFzEkeRykAy3LaQ-fb3mW9-GiM86q0LjVFoSuzaJySnMo4jiVrybMd2STtiWpZ21LXa_X7bwuEW2BlC7P-22NQG4-q9ag2HtXg_nmT_7x13nz-8bp-V1xQwdTrZKRk9AQPk4FQkv4AzENyXA</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>Saad, G. S. Abi</creator><creator>Musallam, K. M.</creator><creator>Taher, A. T.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201106</creationdate><title>The surgeon and the patient with β-thalassaemia intermedia</title><author>Saad, G. S. Abi ; Musallam, K. M. ; Taher, A. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3253-36496c8783165f20812cd12d0704aa0248dfcd3a895f67bb60678f2f94c005df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anemia - prevention & control</topic><topic>beta-Thalassemia - complications</topic><topic>beta-Thalassemia - surgery</topic><topic>Blood Transfusion - methods</topic><topic>Chelation Therapy - methods</topic><topic>Cholecystectomy - methods</topic><topic>Facial Bones - surgery</topic><topic>Gallstones - surgery</topic><topic>Humans</topic><topic>Intraoperative Care - methods</topic><topic>Intraoperative Complications - prevention & control</topic><topic>Iron Overload - prevention & control</topic><topic>Leg Ulcer - surgery</topic><topic>Osteoporotic Fractures - surgery</topic><topic>Postoperative Complications - prevention & control</topic><topic>Splenectomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saad, G. S. Abi</creatorcontrib><creatorcontrib>Musallam, K. M.</creatorcontrib><creatorcontrib>Taher, A. T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saad, G. S. Abi</au><au>Musallam, K. M.</au><au>Taher, A. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The surgeon and the patient with β-thalassaemia intermedia</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2011-06</date><risdate>2011</risdate><volume>98</volume><issue>6</issue><spage>751</spage><epage>760</epage><pages>751-760</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>Background:
Unlike patients with β‐thalassaemia major, where lifelong transfusion and iron chelation therapy are necessary for survival, patients with β‐thalassaemia intermedia (TI) generally have a milder course and anaemia. The underlying pathophysiology of the disease still allows several complications to manifest. Surgical management during the course of the disease is common but relevant data from the literature have never been reviewed constructively. This aim of this review was to highlight this clinical entity to the surgeon, and ensure optimal and timely intervention.
Methods:
The review was based on potentially relevant studies identified from an electronic search of MEDLINE and PubMed databases. There were no language or publication year restrictions. References in published articles were also reviewed.
Results:
Surgical intervention is often essential to ensure optimal control of the associated morbidity in TI. Several general considerations are necessary before surgical intervention with regard to anaemia, cardiovascular disease, thromboembolic events and the effects of iron overload. Splenectomy, cholecystectomy, leg ulcers, fractures and extramedullary pseudotumours are the most commonly encountered surgical problems related to TI.
Conclusion:
Awareness of TI and its associated morbidity is important so that appropriate preoperative care can occur. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
All surgeons should know about this</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21480198</pmid><doi>10.1002/bjs.7533</doi><tpages>10</tpages></addata></record> |
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| ispartof | British journal of surgery, 2011-06, Vol.98 (6), p.751-760 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Anemia - prevention & control beta-Thalassemia - complications beta-Thalassemia - surgery Blood Transfusion - methods Chelation Therapy - methods Cholecystectomy - methods Facial Bones - surgery Gallstones - surgery Humans Intraoperative Care - methods Intraoperative Complications - prevention & control Iron Overload - prevention & control Leg Ulcer - surgery Osteoporotic Fractures - surgery Postoperative Complications - prevention & control Splenectomy - adverse effects |
| title | The surgeon and the patient with β-thalassaemia intermedia |
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