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Bone morphogenetic protein (BMP)1-3 enhances bone repair

►BMP1-3 isoform circulates in the human plasma. ► BMP1-3 has an important role in bone repair. ► BMP1-3 as a novel biomarker of bone regeneration. ► BMP1-3 enhances formation of mineralized bone matrix. ► BMP1-3 synergizes with BMP7 in bone defect repair. Members of the astacin family of metalloprot...

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Published in:Biochemical and biophysical research communications 2011-04, Vol.408 (1), p.25-31
Main Authors: Grgurevic, Lovorka, Macek, Boris, Mercep, Mladen, Jelic, Mislav, Smoljanovic, Tomislav, Erjavec, Igor, Dumic-Cule, Ivo, Prgomet, Stefan, Durdevic, Dragan, Vnuk, Drazen, Lipar, Marija, Stejskal, Marko, Kufner, Vera, Brkljacic, Jelena, Maticic, Drazen, Vukicevic, Slobodan
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Language:English
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Summary:►BMP1-3 isoform circulates in the human plasma. ► BMP1-3 has an important role in bone repair. ► BMP1-3 as a novel biomarker of bone regeneration. ► BMP1-3 enhances formation of mineralized bone matrix. ► BMP1-3 synergizes with BMP7 in bone defect repair. Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E1 osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2011.03.109