Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes

Type 2 diabetes is a progressive disease and most patients with type 2 diabetes eventually need insulin therapy. The objective of this study was to clarify C-peptide immunoreactivity (CPR), a marker of beta cell function, as a predictor of requirement for insulin therapy. We conducted a retrospectiv...

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Bibliographic Details
Published in:Endocrine Journal 2011, Vol.58(4), pp.315-322
Main Authors: Saisho, Yoshifumi, Kou, Kinsei, Tanaka, Kumiko, Abe, Takayuki, Kurosawa, Hideaki, Shimada, Akira, Meguro, Shu, Kawai, Toshihide, Itoh, Hiroshi
Format: Article
Language:English
Subjects:
Aged
Beta cell function
Blood Glucose - metabolism
C-peptide
C-Peptide - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Female
Humans
Insulin
Insulin - therapeutic use
Insulin-Secreting Cells - physiology
Male
Middle Aged
Postprandial Period
Prognosis
Retrospective Studies
Type 2 diabetes
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Summary:Type 2 diabetes is a progressive disease and most patients with type 2 diabetes eventually need insulin therapy. The objective of this study was to clarify C-peptide immunoreactivity (CPR), a marker of beta cell function, as a predictor of requirement for insulin therapy. We conducted a retrospective study of 579 consecutive subjects with type 2 diabetes who were admitted to our hospital from 2000 to 2007 and were able to be followed up for at least 6 months after discharge. Fasting and postprandial serum CPR and urinary CPR levels had been measured during admission. Information about insulin therapy at the last visit was obtained from medical records. At the last visit, 364 subjects (62.9%) were treated with insulin. Mean interval between discharge and the last visit was 4.5 ± 2.3 years. Serum and urine CPR levels at baseline were significantly associated with insulin treatment at the last visit (P
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K10E-399