All-cause mortality and serum insulin-like growth factor I in primary care patients

Abstract Objective Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study. Desi...

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Bibliographic Details
Published in:Growth hormone & IGF research 2011-04, Vol.21 (2), p.102-106
Main Authors: Friedrich, N, Schneider, H, Dörr, M, Nauck, M, Völzke, H, Klotsche, J, Sievers, C, Pittrow, D, Böhler, S, Lehnert, H, Pieper, L, Wittchen, H.-U, Wallaschofski, H, Stalla, G.K
Format: Article
Language:English
Subjects:
Adult
Advanced Basic Science
Cardiovascular Diseases - mortality
DETECT
Endocrinology & Metabolism
Female
Humans
IGF-I
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - metabolism
Male
Middle Aged
Mortality
Primary care
Primary Health Care
Prospective Studies
Risk
Survival Analysis
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Summary:Abstract Objective Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study. Design DETECT (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment) is a large, multistage, and nationally representative study of primary care patients in Germany. The study population included 2463 men and 3603 women. Death rates were recorded by the respective primary care physician. Serum total IGF-I levels were determined by chemiluminescence immunoassays and categorized into three groups (low, moderate, and high) according to the sex- and age-specific 10th and 90th percentiles. Results Adjusted analyses revealed that men with low [hazard ratio (HR) 1.70 (95% confidence interval [CI] 1.05–2.73), p = 0.03] and high [HR 1.76 (95% CI 1.09–2.85), p = 0.02] IGF-I levels had higher risk of all-cause mortality compared to men with moderate IGF-I levels. The specificity of low IGF-I and high IGF-I levels increased with lower and higher cut-offs, respectively. No such association became apparent in women. Conclusions The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients.
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2011.02.003