Oxidized low-density lipoproteins in cord blood from neonates with intra-uterine growth restriction

• Published in: European journal of obstetrics & gynecology and reproductive biology 2011-05, Vol.156 (1), p.46-49
• Main Authors: Leduc, Line, Delvin, Edgard, Ouellet, Annie, Garofalo, Carole, Grenier, Emilie, Morin, Lucie, Dubé, Johanne, Bouity-Voubou, Maurice, Moutquin, Jean-Marie, Fouron, Jean-Claude, Klam, Stephanie, Levy, Emile
• Format: Article
• Language: English
• Subjects: Acute-Phase Proteins - analysis; Biological and medical sciences; Biomarkers - blood; Cohort Studies; Cytokines - blood; Diseases in Twins - blood; Diseases in Twins - etiology; Diseases in Twins - immunology; Diseases in Twins - physiopathology; Diseases of mother, fetus and pregnancy; Female; Fetal Blood; Fetal Growth Retardation - blood; Fetal Growth Retardation - etiology; Fetal Growth Retardation - immunology; Fetal programming; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Inflammation; Intrauterine growth restriction; Lipoproteins, LDL - blood; Male; Malondialdehyde - blood; Medical sciences; Obstetrics and Gynecology; Oxidative Stress; Placental Insufficiency - diagnostic imaging; Placental Insufficiency - physiopathology; Pregnancy; Pregnancy Proteins - blood; Pregnancy. Fetus. Placenta; Prospective Studies; Twins; Ultrasonography; Umbilical Arteries - diagnostic imaging; Vascular Cell Adhesion Molecule-1 - blood
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2011.01.007

Abstract Objective We verified whether oxidative stress indices (oxidized low-density lipoproteins and malondialdehyde) and inflammatory biomarkers (circulating C-reactive protein, interleukin-6, tumour necrosis factor-α, serum amyloid A and soluble intercellular vascular cell adhesion molecule) are increased in the umbilical vein of placental insufficiency induced intra-uterine growth restricted neonates. Study design The prospective cohort study, involving 3 tertiary care centers, consists of 200 consecutively recruited pregnant women carrying twins. We chose the twin pregnancy model because both fetuses share the same maternal environment, thereby avoiding potential confounding factors when comparing oxidative stress and inflammation biomarkers. We analysed only twin pairs with one with intra-uterine growth restriction ( N = 38) defined as fetal growth < 10th percentile with abnormal Doppler of the umbilical artery. Blood samples were taken at birth from the umbilical vein. Intra-pair comparisons on the biomarkers were performed using the Student paired t -test. Results We observed increased cord blood levels of oxidized low-density lipoproteins, (2.394 ± .412 vs 1.296 ± .204, p = .003) but not of malondialdehyde in growth restricted neonates when compared to their normal counterparts. Although indices of inflammation tended to be increased in cord blood from growth restricted newborns, the difference did not reach statistical significance. Conclusion In the twin model, intra-uterine growth restriction is associated with low-density lipoprotein oxidation without apparent dysregulation of inflammation biomarkers. Condensation Increased oxidized low-density lipoproteins are observed in growth restricted twins compared to their co-twins with normal growth at birth.