Severe malaria in an unstable setting: clinical and laboratory correlates of cerebral malaria and severe malarial anemia and a paradigm for a simplified severity scoring

An interpretation of historical, clinical, and laboratory data was made to identify the correlates of and the diversity between cerebral malaria (CM) and severe malarial anemia (SMA) in a setting of low, seasonal, and unstable malaria transmission in eastern Sudan. Hemoglobin (Hb), random blood gluc...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2009-06, Vol.28 (6), p.661-665
Main Authors: Giha, H. A, Elghazali, G, A-Elgadir, T. M. E, A-Elbasit, I. E, Elbashir, M. I
Format: Article
Language:English
Subjects:
Anemia
Anemia - pathology
Anemias. Hemoglobinopathies
Antibodies
Antibodies, Protozoan - blood
Biochemistry
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Child
Child, Preschool
Concise Article
Disease transmission
Diseases of red blood cells
Epidemics
Fatalities
Female
Fever
Hematologic and hematopoietic diseases
Hemoglobins - analysis
Hepatomegaly
Human protozoal diseases
Humans
Infectious diseases
Internal Medicine
Laboratories
Liver - pathology
Malaria
Malaria - complications
Malaria - pathology
Malaria, Cerebral - pathology
Male
Medical Microbiology
Medical sciences
Parasitic diseases
Protozoal diseases
Questionnaires
Seasons
Severity of Illness Index
Spleen
Spleen - pathology
Splenomegaly
Sudan
Vector-borne diseases
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Summary:An interpretation of historical, clinical, and laboratory data was made to identify the correlates of and the diversity between cerebral malaria (CM) and severe malarial anemia (SMA) in a setting of low, seasonal, and unstable malaria transmission in eastern Sudan. Hemoglobin (Hb), random blood glucose (RBG), and anti-MSP antibodies were measured. Results showed that SMA and CM were significantly different with regard to age, malaria history, fever duration, convulsions, and hepatosplenomegaly. The MSP Ab response was inversely correlated with the number of previous malaria episodes but not with fever duration in the current attack. The spleen size was significantly inversely correlated with Hb level while hepatomegaly was significantly associated with low RBG. Furthermore, two malaria patients presented with neuropsychiatric upset. Finally, the correlates of SMA and CM fit perfectly with an adopted severity numeric scoring.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-008-0665-5