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Intrauterine infection/inflammation and perinatal brain damage: Role of glial cells and Toll-like receptor signaling
Abstract The mechanisms or pathophysiology that leads to preterm brain damage including white matter damage during development are complex and not fully understood. Intrauterine infection/inflammation can significantly affect perinatal brain development and result in significant alterations in brain...
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Published in: | Journal of neuroimmunology 2010-12, Vol.229 (1), p.16-25 |
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description | Abstract The mechanisms or pathophysiology that leads to preterm brain damage including white matter damage during development are complex and not fully understood. Intrauterine infection/inflammation can significantly affect perinatal brain development and result in significant alterations in brain structure and function. Glial cells and Toll-like receptors (TLRs) are vital players in central nervous system immune response; dysregulation of this response plays an important role in brain damage. Intrauterine infection/inflammation has immunomodulatory effects and induces specific alterations in the TLRs response in many tissues. Recent findings indicate that intrauterine infection/inflammation could promote inflammatory processes in brain and in glial cells by up-regulating cytokines and inflammatory mediators, and by activating signaling pathways and transcriptional factors (nuclear factor-kappaB) implicated in inflammatory injury. TLRs may be involved in intrauterine infection-mediated inflammatory signaling, and intrauterine infection/inflammation could interfere with the TLR4 recruitment into the lipid rafts, leading to an effect on the TLR signaling transduction. In summary, current results suggest that TLRs are key mediators of intrauterine infection/inflammation induced preterm brain damage. |
doi_str_mv | 10.1016/j.jneuroim.2010.08.008 |
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Intrauterine infection/inflammation can significantly affect perinatal brain development and result in significant alterations in brain structure and function. Glial cells and Toll-like receptors (TLRs) are vital players in central nervous system immune response; dysregulation of this response plays an important role in brain damage. Intrauterine infection/inflammation has immunomodulatory effects and induces specific alterations in the TLRs response in many tissues. Recent findings indicate that intrauterine infection/inflammation could promote inflammatory processes in brain and in glial cells by up-regulating cytokines and inflammatory mediators, and by activating signaling pathways and transcriptional factors (nuclear factor-kappaB) implicated in inflammatory injury. TLRs may be involved in intrauterine infection-mediated inflammatory signaling, and intrauterine infection/inflammation could interfere with the TLR4 recruitment into the lipid rafts, leading to an effect on the TLR signaling transduction. In summary, current results suggest that TLRs are key mediators of intrauterine infection/inflammation induced preterm brain damage.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2010.08.008</identifier><identifier>PMID: 20826013</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Brain Diseases - etiology ; Brain Diseases - immunology ; Brain Diseases - pathology ; Female ; Glial cell ; Humans ; Inflammation ; Intrauterine infection ; Models, Biological ; Neuroglia - physiology ; Neurology ; Pregnancy ; Pregnancy Complications, Infectious - immunology ; Pregnancy Complications, Infectious - metabolism ; Pregnancy Complications, Infectious - pathology ; Signal Transduction - physiology ; Toll-like receptors ; Toll-Like Receptors - metabolism ; White matter damage</subject><ispartof>Journal of neuroimmunology, 2010-12, Vol.229 (1), p.16-25</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. 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Intrauterine infection/inflammation can significantly affect perinatal brain development and result in significant alterations in brain structure and function. Glial cells and Toll-like receptors (TLRs) are vital players in central nervous system immune response; dysregulation of this response plays an important role in brain damage. Intrauterine infection/inflammation has immunomodulatory effects and induces specific alterations in the TLRs response in many tissues. Recent findings indicate that intrauterine infection/inflammation could promote inflammatory processes in brain and in glial cells by up-regulating cytokines and inflammatory mediators, and by activating signaling pathways and transcriptional factors (nuclear factor-kappaB) implicated in inflammatory injury. TLRs may be involved in intrauterine infection-mediated inflammatory signaling, and intrauterine infection/inflammation could interfere with the TLR4 recruitment into the lipid rafts, leading to an effect on the TLR signaling transduction. In summary, current results suggest that TLRs are key mediators of intrauterine infection/inflammation induced preterm brain damage.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Brain Diseases - etiology</subject><subject>Brain Diseases - immunology</subject><subject>Brain Diseases - pathology</subject><subject>Female</subject><subject>Glial cell</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intrauterine infection</subject><subject>Models, Biological</subject><subject>Neuroglia - physiology</subject><subject>Neurology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Pregnancy Complications, Infectious - metabolism</subject><subject>Pregnancy Complications, Infectious - pathology</subject><subject>Signal Transduction - physiology</subject><subject>Toll-like receptors</subject><subject>Toll-Like Receptors - metabolism</subject><subject>White matter damage</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkktv1DAQgC0EokvhL1S-ccrWY8exwwGBKh6VKiFBOVtOMlk5dezFTpD673HYlgOXnvz6Zsaabwi5ALYHBs3ltJ8Crim6ec9ZuWR6z5h-RnagFa90zeE52RVQVlJxfUZe5TwxBlLU7UtyxpnmDQOxI8t1WJJdF0wuIHVhxH5xMVyWnbfzbLcDtWGgx42wi_W0S9YFOtjZHvAd_R490jjSg3flrUfv81_-NnpfeXeHNGGPxyUmmt0hWO_C4TV5MVqf8c3Dek5-fv50e_W1uvn25frq403VS86WSgg1ajmCkK1CFGKwrdYjykbXbTdarWu0g2qFUoOQ0FnZqU41ko3QNKyrQZyTt6e8xxR_rZgXM7u8fdEGjGs2uqlbCQDiaRI4CF43qpDNiexTzDnhaI7JzTbdG2BmU2Mm86jGbGoM06aoKYEXDyXWbsbhX9ijiwJ8OAFYWvLbYTK5dxh6HFxp4WKG6J6u8f6_FH3pt-utv8N7zFNcUzGQDZjMDTM_tgHZ5gMYY0JxIf4AgYe49g</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Yuan, Tian-Ming</creator><creator>Sun, Yi</creator><creator>Zhan, Can-Yang</creator><creator>Yu, Hui-Min</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20101215</creationdate><title>Intrauterine infection/inflammation and perinatal brain damage: Role of glial cells and Toll-like receptor signaling</title><author>Yuan, Tian-Ming ; Sun, Yi ; Zhan, Can-Yang ; Yu, Hui-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-337f85f13597ee33da988fe56849bfa884ead79377d351ba5b7b7650f1660b413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Brain Diseases - etiology</topic><topic>Brain Diseases - immunology</topic><topic>Brain Diseases - pathology</topic><topic>Female</topic><topic>Glial cell</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intrauterine infection</topic><topic>Models, Biological</topic><topic>Neuroglia - physiology</topic><topic>Neurology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>Pregnancy Complications, Infectious - metabolism</topic><topic>Pregnancy Complications, Infectious - pathology</topic><topic>Signal Transduction - physiology</topic><topic>Toll-like receptors</topic><topic>Toll-Like Receptors - metabolism</topic><topic>White matter damage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Tian-Ming</creatorcontrib><creatorcontrib>Sun, Yi</creatorcontrib><creatorcontrib>Zhan, Can-Yang</creatorcontrib><creatorcontrib>Yu, Hui-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Tian-Ming</au><au>Sun, Yi</au><au>Zhan, Can-Yang</au><au>Yu, Hui-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrauterine infection/inflammation and perinatal brain damage: Role of glial cells and Toll-like receptor signaling</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>229</volume><issue>1</issue><spage>16</spage><epage>25</epage><pages>16-25</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract The mechanisms or pathophysiology that leads to preterm brain damage including white matter damage during development are complex and not fully understood. Intrauterine infection/inflammation can significantly affect perinatal brain development and result in significant alterations in brain structure and function. Glial cells and Toll-like receptors (TLRs) are vital players in central nervous system immune response; dysregulation of this response plays an important role in brain damage. Intrauterine infection/inflammation has immunomodulatory effects and induces specific alterations in the TLRs response in many tissues. Recent findings indicate that intrauterine infection/inflammation could promote inflammatory processes in brain and in glial cells by up-regulating cytokines and inflammatory mediators, and by activating signaling pathways and transcriptional factors (nuclear factor-kappaB) implicated in inflammatory injury. TLRs may be involved in intrauterine infection-mediated inflammatory signaling, and intrauterine infection/inflammation could interfere with the TLR4 recruitment into the lipid rafts, leading to an effect on the TLR signaling transduction. In summary, current results suggest that TLRs are key mediators of intrauterine infection/inflammation induced preterm brain damage.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20826013</pmid><doi>10.1016/j.jneuroim.2010.08.008</doi><tpages>10</tpages></addata></record> |
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subjects | Allergy and Immunology Animals Brain Diseases - etiology Brain Diseases - immunology Brain Diseases - pathology Female Glial cell Humans Inflammation Intrauterine infection Models, Biological Neuroglia - physiology Neurology Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - metabolism Pregnancy Complications, Infectious - pathology Signal Transduction - physiology Toll-like receptors Toll-Like Receptors - metabolism White matter damage |
title | Intrauterine infection/inflammation and perinatal brain damage: Role of glial cells and Toll-like receptor signaling |
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