Mitochondrial permeability transition triggers the release of mtDNA fragments

Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent re...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2004-12, Vol.61 (24), p.3100-3103
Main Authors: Patrushev, M, Kasymov, V, Patrusheva, V, Ushakova, T, Gogvadze, V, Gaziev, A
Format: Article
Language:English
Subjects:
Animals
Cellular biology
Cyclosporine - pharmacology
DNA, Mitochondrial - metabolism
Ion Channels - physiology
Mice
Mice, Inbred BALB C
Mitochondria, Liver - drug effects
Mitochondria, Liver - physiology
Mitochondrial DNA
Mitochondrial Membrane Transport Proteins
Permeability
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Summary:Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent release of the fragments of mitochondrial DNA could be one cause of genomic instability in the cell.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-004-4424-1